{"id":"W4413760558","doi":"10.1016/j.str.2025.08.001","title":"Design of a selective peptide inhibitor targeting KDM5C demethylase activity","year":2025,"lang":"en","type":"article","venue":"Structure","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Demethylase; Chemistry; Peptide; Computational biology; Biochemistry; Biology; Epigenetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402244,0.0001200791,0.0001340148,0.00005165042,0.00006396953,0.000009471259,0.00009475191,0.0001711341,0.00001070898],"category_scores_gemma":[0.0002155725,0.0001118431,0.00005266322,0.0001605739,0.00004454839,0.000002704014,0.00006276987,0.000107339,4.012639e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001451393,"about_ca_system_score_gemma":0.0001202467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001515127,"about_ca_topic_score_gemma":0.00001154063,"domain_scores_codex":[0.9992625,0.0001136634,0.0001438579,0.000247108,0.00008570745,0.0001471289],"domain_scores_gemma":[0.9995325,0.00002830482,0.00009502398,0.000177524,0.0001355954,0.0000310723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009528673,0.00001340901,0.001675685,0.00002486151,0.00004861466,3.944457e-7,0.00004517531,0.001400489,0.9921345,0.00003788076,0.0004462422,0.004077523],"study_design_scores_gemma":[0.000267944,0.0001185841,0.003930642,0.00001060001,0.00002100861,2.985777e-7,0.0000218701,0.0001997391,0.9921049,0.001598466,0.001623824,0.0001020707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9263701,0.001143639,0.07158829,0.00003941815,0.0001505838,0.0001898713,0.00002158137,0.000007542029,0.0004890101],"genre_scores_gemma":[0.9916599,0.00006247737,0.007877185,0.0000333655,0.0001143026,0.000005674278,0.00003035467,0.00001060877,0.0002061402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06528983,"threshold_uncertainty_score":0.4560831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00671251450427623,"score_gpt":0.2566763333859323,"score_spread":0.2499638188816561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}