{"id":"W4413766549","doi":"10.1186/s13046-025-03521-5","title":"Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling","year":2025,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Project 211; Xiangya Hospital, Central South University; Higher Education Discipline Innovation Project; Natural Science Foundation of Hunan Province; Central South University; National Natural Science Foundation of China","keywords":"Nivolumab; p38 mitogen-activated protein kinases; Secretion; Cancer research; MAPK/ERK pathway; Medicine; Melanoma; Signal transduction; Apoptosis; Immunotherapy; Pharmacology; Immunology; Chemistry; Immune system; Cell biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004004244,0.0002505606,0.0008962959,0.0004920531,0.0001805129,0.0000848301,0.0004096077,0.0002804249,0.001731805],"category_scores_gemma":[0.0001729115,0.0001984676,0.0005890772,0.0009960512,0.0004943415,0.0002639097,0.0001174592,0.001586015,0.00001098234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008539548,"about_ca_system_score_gemma":0.0008369453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009964004,"about_ca_topic_score_gemma":0.00003628687,"domain_scores_codex":[0.9953962,0.0006061252,0.001871527,0.0004081267,0.001124522,0.0005934985],"domain_scores_gemma":[0.998032,0.0005469711,0.0004136404,0.0003525448,0.0004885761,0.0001662111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0175541,0.001301755,0.04373261,0.00005538689,0.0006926053,0.0002205193,0.0005290289,0.00001399271,0.917812,0.00008551901,0.002827239,0.01517526],"study_design_scores_gemma":[0.02461714,0.006800258,0.09055173,0.002884293,0.00008998421,0.0001653934,0.002818148,0.0002160107,0.8301899,0.0008484643,0.0404035,0.0004151604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9406694,0.05230995,0.0002261623,0.003762825,0.001396064,0.000522727,0.000008193537,0.00001600688,0.001088741],"genre_scores_gemma":[0.9848544,0.01192467,0.0005922525,0.001187266,0.0007109171,0.00003828108,0.000007959182,0.00003857869,0.0006456897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08762208,"threshold_uncertainty_score":0.9991807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1130832919598193,"score_gpt":0.5070031900593935,"score_spread":0.3939198980995742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}