{"id":"W4413769452","doi":"10.1002/anie.202513768","title":"Rapid and Modular Access to All‐Carbon Quaternary Center‐Containing 2,2‐Disubstituted Bicyclo[1.1.1]pentanes via Cyanocarbene Addition to Bicyclo[1.1.0]butanes","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Key Research and Development Program of China; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Bicyclic molecule; Modular design; Center (category theory); Carbon fibers; Chemistry; Stereochemistry; Medicinal chemistry; Materials science; Computer science; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008602739,0.0003706996,0.0001643982,0.0001556417,0.0001505753,0.0001671426,0.0001905513,0.0001504447,0.001287467],"category_scores_gemma":[0.0001314947,0.0001557823,0.0001245512,0.0001433024,0.0001499811,0.0002693474,0.0002790364,0.0004498453,0.0004217188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002215665,"about_ca_system_score_gemma":0.0004045655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004647614,"about_ca_topic_score_gemma":0.001642973,"domain_scores_codex":[0.9999179,0.000009799451,0.000007048674,0.00001697439,0.0000183074,0.0000300074],"domain_scores_gemma":[0.9999567,0.000006798018,0.00001259954,0.000005123266,0.000006706246,0.00001199965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302499,0.00006438282,0.0001870429,0.000341019,0.000009267867,0.0002402913,0.0001628465,0.00180062,0.9716743,0.004018672,0.0006485267,0.0207229],"study_design_scores_gemma":[0.00002587626,0.0003144128,0.0006292703,0.00001621511,0.000008749622,0.0002062318,0.00002997962,0.003019482,0.986943,0.0002441286,0.008546551,0.00001604427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553835,0.002875727,0.02197087,0.0001943128,0.0001341539,0.0001504086,0.0004220735,0.0004762529,0.01839277],"genre_scores_gemma":[0.9878939,0.001528919,0.007457788,0.00006088674,0.00001033861,0.00007258059,0.000230545,0.00004355357,0.002701395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287467,"threshold_uncertainty_score":0.004306972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904254212628139,"score_gpt":0.2845761812655005,"score_spread":0.2655336391392191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}