{"id":"W4413769452","doi":"10.1002/anie.202513768","title":"Rapid and Modular Access to All‐Carbon Quaternary Center‐Containing 2,2‐Disubstituted Bicyclo[1.1.1]pentanes via Cyanocarbene Addition to Bicyclo[1.1.0]butanes","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Key Research and Development Program of China; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Bicyclic molecule; Modular design; Center (category theory); Carbon fibers; Chemistry; Stereochemistry; Medicinal chemistry; Materials science; Computer science; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001453373,0.00044653,0.0003635522,0.0005456267,0.0001589904,0.0003105197,0.0005863716,0.0002440229,0.000878193],"category_scores_gemma":[0.0001818453,0.0004965048,0.0001319388,0.0003626276,0.0000498866,0.0006905928,0.0003921245,0.0002897872,0.00004031093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006573059,"about_ca_system_score_gemma":0.00006178101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003525557,"about_ca_topic_score_gemma":0.00009410924,"domain_scores_codex":[0.9974056,0.00002486253,0.0005940893,0.0008807158,0.0006597014,0.0004349667],"domain_scores_gemma":[0.9986252,0.000109078,0.0002198307,0.0004006191,0.0003671228,0.0002781986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005197281,0.0001719434,0.001670132,0.000156951,0.0002653949,0.00007782839,0.0003701715,0.0001252232,0.9812361,0.0002023804,0.002105115,0.01309902],"study_design_scores_gemma":[0.001109364,0.00006232577,0.001132339,0.0005238827,0.0000797102,0.0001075699,0.0003638946,0.0006790181,0.9474478,0.0009093144,0.04711575,0.0004690078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621226,0.0002533442,0.007153773,0.004757049,0.003181105,0.0005263052,0.0004896075,0.0004701496,0.02104613],"genre_scores_gemma":[0.991941,0.0002501287,0.0005455503,0.001823841,0.00159948,0.0003421137,0.002905185,0.000058183,0.0005345116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04501064,"threshold_uncertainty_score":0.9997486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904254212628139,"score_gpt":0.2845761812655005,"score_spread":0.2655336391392191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}