{"id":"W4413769871","doi":"10.1002/ange.202513768","title":"Rapid and Modular Access to All‐Carbon Quaternary Center‐Containing 2,2‐Disubstituted Bicyclo[1.1.1]pentanes via Cyanocarbene Addition to Bicyclo[1.1.0]butanes","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Key Research and Development Program of China; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Bicyclic molecule; Chemistry; Modular design; Center (category theory); Carbon fibers; Stereochemistry; Medicinal chemistry; Materials science; Computer science; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001452108,0.0005835821,0.0005811203,0.0003870571,0.0002010064,0.0002689878,0.0006041952,0.0002959082,0.0004710162],"category_scores_gemma":[0.0001126499,0.0006196562,0.000146367,0.000574654,0.00005510365,0.0003847819,0.0005443245,0.0003199349,0.00003781941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990235,"about_ca_system_score_gemma":0.00007189377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004743332,"about_ca_topic_score_gemma":0.0001358027,"domain_scores_codex":[0.9971575,0.00002944077,0.0005870309,0.001068643,0.000449136,0.0007083233],"domain_scores_gemma":[0.9983657,0.0001000163,0.0001749619,0.0007587781,0.0001659185,0.0004346423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003688354,0.0001150054,0.002673571,0.0003344519,0.0001905444,0.0001306449,0.0005001072,0.00004271149,0.9839856,0.00003977889,0.0005900624,0.01102869],"study_design_scores_gemma":[0.001118708,0.00007044522,0.0006172138,0.0004650605,0.0001299759,0.0001023023,0.0005107229,0.0001404161,0.9570737,0.000280125,0.0388738,0.000617468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819962,0.0008341547,0.0003891521,0.001344467,0.0005039292,0.0004897398,0.0001366478,0.0004577963,0.01384785],"genre_scores_gemma":[0.9954894,0.0003405448,0.0005532131,0.001568981,0.0003965595,0.0002739109,0.000574359,0.00008713801,0.0007158595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03828374,"threshold_uncertainty_score":0.9996255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159539110143335,"score_gpt":0.2749689901974944,"score_spread":0.2533735990960611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}