{"id":"W4413774493","doi":"10.1016/s2152-2650(25)02385-7","title":"ABCL-1487: Large B-Cell Lymphoma Microenvironment Archetype Profiles (LymphoMAPs) Clinically Identify Subgroups With Greatest Benefit From CD19 CAR T-Cell Therapy","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"Medicine; CD19; Lymphoma; Oncology; Internal medicine; Immunology; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002985266,0.0003082105,0.0003619706,0.0007820969,0.0004050408,0.0009995693,0.0002806342,0.0003880835,0.005373718],"category_scores_gemma":[0.0005475213,0.0001015629,0.0002963835,0.0005369131,0.0003146215,0.0005368054,0.0005796979,0.0004627992,0.001202403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004501143,"about_ca_system_score_gemma":0.0002622708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005877799,"about_ca_topic_score_gemma":0.00134158,"domain_scores_codex":[0.9998066,0.0000314418,0.0000161162,0.00004159633,0.00004056728,0.00006377255],"domain_scores_gemma":[0.9997337,0.0000475053,0.00008744139,0.00001873678,0.00003476079,0.00007770333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005587866,0.0002395586,0.787665,0.0001196256,0.0002433789,0.001527476,0.0001837178,0.0006448588,0.1101809,0.0014327,0.004369378,0.08780541],"study_design_scores_gemma":[0.0002798164,0.001200368,0.943738,0.0000425898,0.0002881428,0.01045915,0.0008876604,0.004221815,0.02445504,0.003895522,0.01050088,0.00003096884],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942402,0.0004020782,0.0005851729,0.0002502761,0.00001129103,0.00004618374,0.0006769303,0.00004567883,0.003742191],"genre_scores_gemma":[0.9975673,0.00008180572,0.0005512976,0.0001270171,0.000019034,0.00002422309,0.001009308,0.00001457362,0.0006055598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005373718,"threshold_uncertainty_score":0.01797688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548499021004296,"score_gpt":0.3236153303053004,"score_spread":0.2981303400952574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}