{"id":"W4413780225","doi":"10.1111/ctr.70278","title":"Effectiveness and Safety of Switching to Ravulizumab From Eculizumab in Kidney Transplant Recipients With Atypical Hemolytic Uremic Syndrome: A Global aHUS Registry Analysis","year":2025,"lang":"en","type":"article","venue":"Clinical Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brampton Civic Hospital","funders":"Universitätsklinikum Tübingen; Universitätsklinikum Heidelberg; Odense Universitetshospital; Newcastle upon Tyne Hospitals NHS Foundation Trust; AstraZeneca; University College London; University College London Hospitals NHS Foundation Trust; Georgetown University; Universitätsklinikum Essen; Alexion Pharmaceuticals","keywords":"Medicine; Atypical hemolytic uremic syndrome; Eculizumab; Kidney transplantation; Intensive care medicine; Immunology; Pediatrics; Kidney; Internal medicine; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005092325,0.0002044682,0.0007596256,0.000175108,0.00007460736,0.00001174559,0.0002097991,0.0002283913,0.00005354844],"category_scores_gemma":[0.0001350043,0.0001795243,0.0001652447,0.000690171,0.0001226608,0.00006200191,0.00002090443,0.0002205844,0.000009255356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001012282,"about_ca_system_score_gemma":0.0001451027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004744915,"about_ca_topic_score_gemma":0.0005368872,"domain_scores_codex":[0.9974354,0.0007715803,0.0008926605,0.000583443,0.00007893034,0.000237984],"domain_scores_gemma":[0.9982978,0.001120435,0.0001501759,0.0003068432,0.00004745261,0.00007734953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02195979,0.0003076395,0.9704949,0.0004144554,0.001560658,0.00008715907,0.0002174383,0.0001990271,0.002729314,0.0002444106,0.00001978319,0.001765382],"study_design_scores_gemma":[0.007794135,0.0002641691,0.9860719,0.002672625,0.00176233,0.00004576533,0.0000505367,0.00005027666,0.0008737866,0.0002208256,0.00002016882,0.0001734232],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719701,0.0002802277,0.02554801,0.0001202538,0.0002676163,0.0006604806,0.001027771,0.00003290234,0.00009268551],"genre_scores_gemma":[0.9987203,0.0001032981,0.0002269829,0.00008889792,0.000005433594,0.00004028164,0.0007982221,0.000006952214,0.000009579439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0267503,"threshold_uncertainty_score":0.7320789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309985654920963,"score_gpt":0.3173876273693751,"score_spread":0.3042877708201655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}