{"id":"W4413780225","doi":"10.1111/ctr.70278","title":"Effectiveness and Safety of Switching to Ravulizumab From Eculizumab in Kidney Transplant Recipients With Atypical Hemolytic Uremic Syndrome: A Global aHUS Registry Analysis","year":2025,"lang":"en","type":"article","venue":"Clinical Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brampton Civic Hospital","funders":"Universitätsklinikum Tübingen; Universitätsklinikum Heidelberg; Odense Universitetshospital; Newcastle upon Tyne Hospitals NHS Foundation Trust; AstraZeneca; University College London; University College London Hospitals NHS Foundation Trust; Georgetown University; Universitätsklinikum Essen; Alexion Pharmaceuticals","keywords":"Medicine; Atypical hemolytic uremic syndrome; Eculizumab; Kidney transplantation; Intensive care medicine; Immunology; Pediatrics; Kidney; Internal medicine; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006678383,0.0003307507,0.0008469179,0.000910008,0.000204867,0.001252128,0.0005035035,0.000430338,0.0007479895],"category_scores_gemma":[0.007673706,0.000203075,0.001999299,0.001484621,0.000438254,0.0009226903,0.0007467801,0.0006778645,0.0001140182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007532563,"about_ca_system_score_gemma":0.0006611295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007694252,"about_ca_topic_score_gemma":0.001218117,"domain_scores_codex":[0.995396,0.002185064,0.0007149575,0.0007696966,0.0006705412,0.0002637754],"domain_scores_gemma":[0.9871508,0.003035404,0.007907235,0.0006767046,0.0005037825,0.0007260811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008843937,0.0003422792,0.9586775,0.0004070753,0.004051552,0.000100635,0.0001342399,0.001163708,0.0005195432,0.0001172821,0.0008946527,0.02474762],"study_design_scores_gemma":[0.001816492,0.004916882,0.9832617,0.0001769699,0.004725866,0.0005861412,0.0002136393,0.002054178,0.0006957387,0.000163024,0.0013467,0.00004265889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952579,0.002661299,0.0001738628,0.0001411405,0.0000102723,0.00003892359,0.001082428,0.00001166602,0.0006223784],"genre_scores_gemma":[0.9977306,0.0006526054,0.0001931717,0.00008920768,0.00002403971,0.00003766923,0.001221606,0.000004577368,0.0000466069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006678383,"threshold_uncertainty_score":0.03531909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309985654920963,"score_gpt":0.3173876273693751,"score_spread":0.3042877708201655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}