{"id":"W4413782934","doi":"10.1016/s2152-2650(25)02033-6","title":"MDS-736: Preliminary Efficacy and Safety Analysis of the MAXILUS Study of Luspatercept (LUSPA) Initiated at the Maximum Approved Dose in Transfusion-Dependent (TD) Lower-Risk Myelodysplastic Syndromes (LR-MDS)","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Myelodysplastic syndromes; Internal medicine; Oncology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002138135,0.00137359,0.001552286,0.0005433244,0.0003918041,0.001290411,0.0007824371,0.000913033,0.004198979],"category_scores_gemma":[0.0012258,0.0004694065,0.00136792,0.0004875536,0.001026608,0.0007617031,0.0002927319,0.003183798,0.001190298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001163443,"about_ca_system_score_gemma":0.001563292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001231372,"about_ca_topic_score_gemma":0.003201838,"domain_scores_codex":[0.999376,0.0003199985,0.00002664106,0.00007334119,0.00007869967,0.0001252445],"domain_scores_gemma":[0.9991026,0.000213336,0.0001686824,0.00008270796,0.00004117479,0.0003915925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6847715,0.03250161,0.01260116,0.0009699747,0.002524448,0.0005276478,0.0004021691,0.007363576,0.07249518,0.001180501,0.01282238,0.1718398],"study_design_scores_gemma":[0.3246635,0.5760748,0.05417471,0.0001250556,0.002171807,0.001336298,0.0001380703,0.005667604,0.01985856,0.0009907028,0.01466248,0.0001364419],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985225,0.003601963,0.001022569,0.0007470077,0.00008780639,0.000778744,0.003891795,0.0002824215,0.004362613],"genre_scores_gemma":[0.9897886,0.001378933,0.001270164,0.0005837455,0.0001417014,0.0005056311,0.004507578,0.00006365858,0.001759996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004198979,"threshold_uncertainty_score":0.01404697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927636750517353,"score_gpt":0.331168041918095,"score_spread":0.3018916744129214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}