{"id":"W4413783181","doi":"10.1016/s2152-2650(25)01940-8","title":"CML-575: ENABLE: A Phase 1a/1b Study of ELVN-001, a Selective Active Site Inhibitor of BCR::ABL1, in Patients With Previously Treated Chronic Myeloid Leukemia","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Myeloid leukemia; Internal medicine; breakpoint cluster region; Oncology; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001869254,0.001261033,0.001386505,0.0004937283,0.0003748146,0.001085514,0.0008940742,0.001074995,0.004656746],"category_scores_gemma":[0.0007465855,0.0005545938,0.0009192883,0.0004536854,0.0009842265,0.000817773,0.0004555128,0.003175721,0.00107119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00103511,"about_ca_system_score_gemma":0.001482383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663342,"about_ca_topic_score_gemma":0.005817869,"domain_scores_codex":[0.9996325,0.0001677239,0.00001431139,0.0000461368,0.00004004102,0.0000993111],"domain_scores_gemma":[0.9995853,0.0000680612,0.00006036079,0.00002742588,0.00001935717,0.0002394224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4886024,0.0848986,0.01777042,0.001563527,0.002324695,0.0004792613,0.0006676373,0.006541159,0.08984409,0.002232102,0.02222019,0.282856],"study_design_scores_gemma":[0.6459805,0.2989952,0.02898112,0.0001097769,0.0008484837,0.0005843189,0.0001823564,0.002035537,0.007870099,0.0005299873,0.01381815,0.00006452402],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867697,0.003739289,0.0005508004,0.001273358,0.0001945698,0.001272707,0.001885247,0.0001458096,0.004168478],"genre_scores_gemma":[0.9798545,0.004465441,0.001994058,0.002122648,0.0002055623,0.001563044,0.004701984,0.00006891874,0.005023844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004656746,"threshold_uncertainty_score":0.01557833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251235163430183,"score_gpt":0.3084303981712043,"score_spread":0.2959180465369025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}