{"id":"W4413788439","doi":"10.1016/s2152-2650(25)02630-8","title":"MM-691: Phase 3 AQUILA Study of Daratumumab Monotherapy Versus Active Monitoring in Patients With High-Risk Smoldering Multiple Myeloma (SMM)","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Daratumumab; Multiple myeloma; Oncology; Internal medicine; Bortezomib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001223575,0.001393743,0.001920801,0.0004699281,0.0004127749,0.001392153,0.0008998857,0.00113603,0.004563191],"category_scores_gemma":[0.0008956643,0.0005011332,0.00190365,0.0003555922,0.0006851217,0.0009468623,0.0004101399,0.00377306,0.001041799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001082948,"about_ca_system_score_gemma":0.001199606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00161853,"about_ca_topic_score_gemma":0.004923382,"domain_scores_codex":[0.9997028,0.0001198258,0.00001167221,0.00005538595,0.0000311757,0.00007907762],"domain_scores_gemma":[0.9995542,0.00008741618,0.00009595279,0.00002124552,0.0000236158,0.0002175377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7744051,0.02031999,0.007248476,0.001293339,0.003195812,0.0002034972,0.0002945171,0.003266105,0.02055626,0.000973893,0.01377361,0.1544695],"study_design_scores_gemma":[0.8166219,0.1519747,0.01754948,0.0001156424,0.001466827,0.0003625865,0.00009771408,0.002192682,0.001932488,0.0006904168,0.00692057,0.00007497295],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796623,0.008257221,0.0006786054,0.001973867,0.0004847102,0.001170949,0.002807582,0.000338089,0.004626811],"genre_scores_gemma":[0.9810193,0.004206313,0.002057287,0.002955077,0.0003634967,0.001141781,0.003476027,0.00007148639,0.004709166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004563191,"threshold_uncertainty_score":0.01526535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03567797545871287,"score_gpt":0.3661947868512335,"score_spread":0.3305168113925206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}