{"id":"W4413789586","doi":"10.21203/rs.3.rs-7232328/v1","title":"Rectal Nanoparticulate-Hydrogel Delivery of Corticosteroid Altering Enterohepatic Metabolism and Clearance for Improved Drug Disposition","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; China Scholarship Council; University of Toronto; Northwestern Polytechnical University; National Natural Science Foundation of China; Northwestern University","keywords":"Budesonide; Enterohepatic circulation; Pharmacokinetics; Pharmacology; Metabolite; Drug metabolism; Chemistry; Active metabolite; Prodrug; Drug delivery; First pass effect; Metabolism; Oral administration; CYP3A4; Bioavailability; Drug; Cytochrome P450; Corticosteroid; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001799947,0.0003815909,0.0007924894,0.0003924201,0.0003398346,0.00005326677,0.0004274802,0.0005006414,0.00003699485],"category_scores_gemma":[0.0002849988,0.0003916347,0.000233911,0.0002469516,0.0003702905,0.0001658399,0.001088307,0.001698213,0.000009643541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002150768,"about_ca_system_score_gemma":0.0002265841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001724559,"about_ca_topic_score_gemma":0.00007157319,"domain_scores_codex":[0.9960797,0.001088495,0.0008275876,0.0008302766,0.0003605295,0.0008134565],"domain_scores_gemma":[0.9968754,0.00122126,0.0003377085,0.0005160071,0.0007870967,0.0002625151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0101573,0.001224064,0.006407513,0.02339716,0.001909009,0.00006825777,0.006127426,0.01267055,0.8701397,0.0007776791,0.001597013,0.06552432],"study_design_scores_gemma":[0.007303854,0.0006749845,0.005845305,0.004548027,0.0008736588,0.00003287785,0.001001819,0.474073,0.4811969,0.003549249,0.01958227,0.001318029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835595,0.008575286,0.0009336451,0.0002683452,0.001414748,0.003735642,0.001324257,0.00008181082,0.0001066946],"genre_scores_gemma":[0.994903,0.002436671,0.0005041189,0.00009429544,0.0002319269,0.0009622803,0.0001844437,0.00004501599,0.0006382521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4614024,"threshold_uncertainty_score":0.9998536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057576374402888,"score_gpt":0.470353504066744,"score_spread":0.3645958666264552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}