{"id":"W4413789586","doi":"10.21203/rs.3.rs-7232328/v1","title":"Rectal Nanoparticulate-Hydrogel Delivery of Corticosteroid Altering Enterohepatic Metabolism and Clearance for Improved Drug Disposition","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; China Scholarship Council; University of Toronto; Northwestern Polytechnical University; National Natural Science Foundation of China; Northwestern University","keywords":"Budesonide; Enterohepatic circulation; Pharmacokinetics; Pharmacology; Metabolite; Drug metabolism; Chemistry; Active metabolite; Prodrug; Drug delivery; First pass effect; Metabolism; Oral administration; CYP3A4; Bioavailability; Drug; Cytochrome P450; Corticosteroid; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009476567,0.0001794593,0.0001445745,0.00007582417,0.00009761464,0.0002438129,0.0001263591,0.0002065757,0.001523842],"category_scores_gemma":[0.0001529879,0.0000745064,0.0001995628,0.00007998238,0.0001159961,0.0002007755,0.000143245,0.0003077518,0.0004119551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821061,"about_ca_system_score_gemma":0.0002803654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001220897,"about_ca_topic_score_gemma":0.001632826,"domain_scores_codex":[0.9999473,0.000006476664,0.000002829126,0.00001216941,0.00001458651,0.00001666752],"domain_scores_gemma":[0.9999481,0.00001077672,0.00001526795,0.000005106603,0.000008623819,0.00001211146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002689471,0.00002516042,0.00005235952,0.00004512037,0.000004681351,0.00004234424,0.000007658646,0.0001316364,0.9943714,0.00006639764,0.00008428533,0.004900195],"study_design_scores_gemma":[0.00001923555,0.0003116801,0.0004917681,0.000003731454,0.00001582915,0.0000992335,0.000006135937,0.001154349,0.9966714,0.00001244142,0.001209369,0.000004828524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850677,0.003510317,0.008864188,0.0001473838,0.0001054936,0.0000480439,0.0002212162,0.0001481179,0.001887616],"genre_scores_gemma":[0.9898182,0.0009964203,0.005957713,0.00005180835,0.000018721,0.00001531137,0.00007752037,0.00003631536,0.003028036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523842,"threshold_uncertainty_score":0.005097806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057576374402888,"score_gpt":0.470353504066744,"score_spread":0.3645958666264552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}