{"id":"W4413789824","doi":"10.1016/s2152-2650(25)02141-x","title":"MPN-785: Results From VERIFY, an International, Randomized, Phase 3, Double-Blind, Placebo-Controlled Study of Rusfertide (First-in-Class Hepcidin Mimetic) for Treatment of Polycythemia Vera (PV)","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Polycythemia vera; Hepcidin; Double blind; Placebo; Internal medicine; Gastroenterology; Anemia; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002107813,0.001593007,0.002563416,0.0005019284,0.000506854,0.001039537,0.00105004,0.001736921,0.006708593],"category_scores_gemma":[0.001745004,0.0006790044,0.001462298,0.000384433,0.001247431,0.001342209,0.0003255885,0.002764217,0.001073755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005615344,"about_ca_system_score_gemma":0.001171471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009457019,"about_ca_topic_score_gemma":0.001986232,"domain_scores_codex":[0.999471,0.0002744704,0.00003589454,0.00008642937,0.00004863405,0.00008363979],"domain_scores_gemma":[0.9991735,0.0002603614,0.0001861681,0.00005594835,0.0000430072,0.0002810089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.961065,0.006974477,0.000467714,0.0008754046,0.0009772165,0.00005632609,0.00005326443,0.0003018594,0.006286708,0.0001793585,0.001338435,0.02142413],"study_design_scores_gemma":[0.9526961,0.04305903,0.001951893,0.00003350757,0.0004709391,0.00005147591,0.0000212979,0.000291184,0.0006823997,0.00009767684,0.0006271534,0.00001735989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719592,0.01165677,0.001943981,0.0009724296,0.0006256899,0.004088297,0.003104545,0.0005300447,0.005118952],"genre_scores_gemma":[0.9808452,0.005515355,0.002828994,0.001696979,0.0005667516,0.002625175,0.002757662,0.0001090945,0.003054767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006708593,"threshold_uncertainty_score":0.02244246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06723351044361701,"score_gpt":0.4040209251642236,"score_spread":0.3367874147206065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}