{"id":"W4413791120","doi":"10.1016/s2152-2650(25)00902-4","title":"POSTER: MPN-780 Safety and Efficacy of Bromodomain and Extra-Terminal (BET) Inhibitor INCB057643 in Patients With Relapsed or Refractory Myelofibrosis (MF) and Other Advanced Myeloid Neoplasms: A Phase 1 Study","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Myelofibrosis; Bromodomain; Refractory (planetary science); Myeloid; Phases of clinical research; Internal medicine; Cancer research; Oncology; Clinical trial; Epigenetics; Bone marrow; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005527784,0.001043209,0.001609532,0.0002762985,0.0003421218,0.0006445079,0.0006001207,0.0009914483,0.0091117],"category_scores_gemma":[0.0003895298,0.000367445,0.001057353,0.0001963782,0.0004425082,0.0005876701,0.0002088624,0.002946377,0.002004418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005219954,"about_ca_system_score_gemma":0.0006871668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005481656,"about_ca_topic_score_gemma":0.0012165,"domain_scores_codex":[0.9998516,0.00004752314,0.000008615604,0.00003207509,0.0000211641,0.00003899942],"domain_scores_gemma":[0.9997862,0.00003748082,0.00004122089,0.00001376092,0.00001338402,0.0001079421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5923478,0.04174784,0.003764066,0.001557735,0.00211353,0.000358275,0.0001583064,0.002701483,0.06223783,0.000410811,0.01782702,0.2747753],"study_design_scores_gemma":[0.5100347,0.4397904,0.02337626,0.0001266365,0.001224643,0.0006302879,0.00006446052,0.001888467,0.01053276,0.0003842337,0.01188111,0.00006600432],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821593,0.00792983,0.0004625239,0.0009545917,0.0003860767,0.000845961,0.001983225,0.0001940401,0.00508457],"genre_scores_gemma":[0.9787971,0.004695918,0.0008725981,0.00171116,0.0004154833,0.0007007274,0.002359104,0.00004654029,0.0104014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0091117,"threshold_uncertainty_score":0.0304817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042447264110488,"score_gpt":0.3417641464352782,"score_spread":0.3213396737941733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}