{"id":"W4413793214","doi":"10.7555/jbr.39.20250189","title":"hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury &lt;i&gt;via&lt;/i&gt; AMPK/NLRP3-mediated pyroptosis suppression and mitochondrial protection","year":2025,"lang":"en","type":"article","venue":"Journal of Biomedical Research","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"","keywords":"Pyroptosis; AMPK; Microvesicles; Medicine; Pharmacology; Chemistry; Internal medicine; microRNA; Biochemistry; Inflammasome; Inflammation; Kinase; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671002,0.0003797987,0.0004111147,0.0002835704,0.0001580929,0.0003662743,0.0001384674,0.0003294996,0.00206941],"category_scores_gemma":[0.0001275195,0.000105562,0.0005055703,0.0001643932,0.0002672562,0.0003619774,0.0002786333,0.0006705959,0.0004738277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000198987,"about_ca_system_score_gemma":0.000311736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003507691,"about_ca_topic_score_gemma":0.0005304274,"domain_scores_codex":[0.9998801,0.00001590557,0.0000195065,0.00002363909,0.0000298547,0.00003103095],"domain_scores_gemma":[0.9999555,0.000004258665,0.00001515225,0.000004692736,0.000007948921,0.00001238238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000920755,0.0001369192,0.0003675187,0.0004269983,0.00004082439,0.0002388973,0.00003731922,0.0002468769,0.9843114,0.0004393774,0.001228484,0.01160459],"study_design_scores_gemma":[0.00005512619,0.0004260642,0.002818035,0.00002609244,0.00006858962,0.0003530273,0.00004804204,0.001051678,0.9851122,0.0001815036,0.009848548,0.00001112831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615374,0.009679939,0.01755506,0.001073731,0.000573238,0.0001924499,0.003641294,0.0008225989,0.004924331],"genre_scores_gemma":[0.9768339,0.005081794,0.007296031,0.0006004585,0.00009118038,0.0001912077,0.003141492,0.000106933,0.006656931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00206941,"threshold_uncertainty_score":0.006922901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456514191512689,"score_gpt":0.2984102841619211,"score_spread":0.2838451422467942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}