{"id":"W4413796114","doi":"10.1016/j.annonc.2025.08.003","title":"Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Diagnosis and Treatment","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Foundation Medicine; Chugai Pharmaceutical; Genentech; Nordic Pharma Group; Sociedad Española de Oncología Médica; PharmaMar; European Society for Medical Oncology; Eisai; Array BioPharma; European School of Oncology; Sanofi; Apollomics; Teva Pharmaceutical Industries; Les Laboratories Pierre Fabre; AstraZeneca; Novocure; Regeneron Pharmaceuticals; International Association for the Study of Lung Cancer; BeiGene; F. Hoffmann-La Roche; Varian Medical Systems; Kasturba Medical College, Manipal; Pfizer; Incyte; Daiichi Sankyo Europe; Gilead Sciences; Roche; Novartis; GlaxoSmithKline; Amgen; Ignyta; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Guideline; Lung cancer; Clinical Practice; Cancer; Oncology; Intensive care medicine; Medical physics; Internal medicine; Family medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004649712,0.0002143579,0.0008283934,0.00008707333,0.00007116495,0.00001111669,0.00006064545,0.0002062984,0.00001697033],"category_scores_gemma":[0.0003750529,0.0001683152,0.0001659693,0.0001075102,0.0001181228,0.00007664125,0.00005966529,0.0001023171,0.000001042178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001706016,"about_ca_system_score_gemma":0.0007771136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065122,"about_ca_topic_score_gemma":0.0005585114,"domain_scores_codex":[0.9983224,0.0000774488,0.0007501803,0.0004706886,0.00008675379,0.0002925148],"domain_scores_gemma":[0.9970443,0.001690128,0.0003037524,0.0002621311,0.0005201923,0.0001794545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003334446,0.002879929,0.3308362,0.0003678945,0.001542633,0.00006041381,0.0003167464,0.0000111342,0.00004682756,0.0002921639,0.07391354,0.5863981],"study_design_scores_gemma":[0.02652479,0.01935344,0.06345371,0.0004707734,0.002485444,0.00001238265,0.0001847562,0.0002548284,0.003918085,0.0001312956,0.8830228,0.0001876356],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8853748,0.03165558,0.0003367233,0.07601226,0.000688249,0.002280127,0.00007251217,0.00002515401,0.003554608],"genre_scores_gemma":[0.7766087,0.1841913,0.01602519,0.01910472,0.0002737517,0.002353336,0.00004518348,0.00003507493,0.001362692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8091093,"threshold_uncertainty_score":0.6863695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05507737742056936,"score_gpt":0.4663043260235319,"score_spread":0.4112269486029626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}