{"id":"W4413796202","doi":"10.3390/proteomes13030040","title":"The Biological Variation in Serum ACE and CPN/CPB2 Activity in Healthy Individuals as Measured by the Degradation of Dabsylated Bradykinin—Reference Data and the Importance of Pre-Analytical Standardization","year":2025,"lang":"en","type":"article","venue":"Proteomes","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brock University; Westfälische Wilhelms-Universität Münster","keywords":"Bradykinin; Population; Carboxypeptidase; Chemistry; Angiotensin-converting enzyme; Enzyme; Medicine; Neuropeptide Y receptor; Internal medicine; Neuropeptide; Biochemistry; Blood pressure","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009174571,0.0004295189,0.0005325802,0.001397418,0.0004513226,0.001082933,0.0008025572,0.0007297784,0.0005930651],"category_scores_gemma":[0.009284561,0.0002062004,0.0004473604,0.001646278,0.0005907771,0.0003091413,0.0006071175,0.0005285567,0.0003521471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004269583,"about_ca_system_score_gemma":0.0003374926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002072737,"about_ca_topic_score_gemma":0.001837693,"domain_scores_codex":[0.9912668,0.002770473,0.001061994,0.002091482,0.00260901,0.0002001967],"domain_scores_gemma":[0.9909621,0.002624639,0.001715322,0.002915688,0.001559935,0.000222435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001540167,0.0003444364,0.8740218,0.0002611871,0.001057759,0.0003277533,0.0009444511,0.001409889,0.06876736,0.00120435,0.002237673,0.04788312],"study_design_scores_gemma":[0.00002607659,0.0006154966,0.9543009,0.00004690381,0.0002683137,0.001232121,0.0002331567,0.002742942,0.03345842,0.0007465265,0.006287385,0.00004169405],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398282,0.003020339,0.04636502,0.0003047015,0.0001674295,0.0002343031,0.006006407,0.0003708845,0.003702659],"genre_scores_gemma":[0.9773973,0.0002859105,0.01550101,0.0002271736,0.0000539203,0.000230008,0.005601858,0.00007924069,0.0006236043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009174571,"threshold_uncertainty_score":0.04852033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04590828807289005,"score_gpt":0.3354520588513899,"score_spread":0.2895437707784999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}