{"id":"W4413799196","doi":"10.1111/jpi.70072","title":"Melatonin Induces PERK‐ATF4 Unfolded Protein Response and Apoptosis in Human Choriocarcinoma Cells","year":2025,"lang":"en","type":"article","venue":"Journal of Pineal Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Institut National de la Recherche Scientifique","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Melatonin; ATF4; Unfolded protein response; Apoptosis; Choriocarcinoma; Biology; Cancer research; Medicine; Internal medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001758928,0.000113507,0.0002015814,0.000401425,0.0001162231,0.00006814252,0.0002600963,0.0001394262,0.00001666459],"category_scores_gemma":[0.0006530971,0.00009474459,0.00007901915,0.0002871711,0.0001650955,0.000009282164,0.0001862612,0.0004220099,0.000001381019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004851137,"about_ca_system_score_gemma":0.0004262545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006514434,"about_ca_topic_score_gemma":0.00001749306,"domain_scores_codex":[0.9982315,0.000488864,0.000375464,0.0002173402,0.0003700443,0.0003168105],"domain_scores_gemma":[0.9991581,0.00007548611,0.000093155,0.0002094204,0.0002904693,0.0001733795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001465591,0.0001224636,0.005524156,0.00005552543,0.00003329623,0.00004150047,0.00006519393,0.000008952645,0.9901733,0.0002040854,0.001337974,0.0009679561],"study_design_scores_gemma":[0.001632992,0.0008042885,0.03311035,0.0001819733,0.000009791418,0.000009264686,0.0003938898,0.00002052325,0.9613618,0.0003665802,0.002009215,0.00009929403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965011,0.001657466,0.00001376912,0.0007763244,0.00005090984,0.0002111216,0.000005434026,0.000001653101,0.0007821723],"genre_scores_gemma":[0.9984601,0.0002371329,0.0001455263,0.00003666558,0.00009748321,0.00001551459,0.000002775456,0.00001011562,0.0009947361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02881147,"threshold_uncertainty_score":0.3863572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502795276104893,"score_gpt":0.3600575067527685,"score_spread":0.3350295539917196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}