{"id":"W4413800386","doi":"10.1101/2025.08.23.671933","title":"GLUCURONIDATION: THE LAST DEFENSIVE LINE AGAINST BILE ACID TOXICITY DURING CHOLESTASIS.","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Canadian Association for the Study of the Liver","keywords":"Glucuronidation; Pregnane X receptor; Cholestasis; Farnesoid X receptor; Enzyme; Chemistry; Bile acid; Hepatocyte; Nuclear receptor; Internal medicine; Biochemistry; Pharmacology; Biology; Medicine; Gene; In vitro; Microsome; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002691718,0.0006023607,0.0003741673,0.0004035598,0.0002154067,0.0005054031,0.0001200809,0.000358154,0.0009460359],"category_scores_gemma":[0.0001761074,0.0001465954,0.00035736,0.0002338659,0.000337655,0.0003232472,0.0003320011,0.0003806146,0.0004442347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661374,"about_ca_system_score_gemma":0.00028233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003450521,"about_ca_topic_score_gemma":0.000483242,"domain_scores_codex":[0.9997784,0.0000624122,0.0000193121,0.00004685455,0.00005738506,0.00003570546],"domain_scores_gemma":[0.9997953,0.00001475078,0.00007626326,0.00002496279,0.00004189049,0.000046881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003790867,0.00001560601,0.005638309,0.0001659789,0.00002788211,0.0001754532,0.00004583154,0.00002802443,0.9827495,0.0001333207,0.000115405,0.01052563],"study_design_scores_gemma":[0.00001614888,0.001346725,0.05292032,0.00003603309,0.00008346602,0.00264957,0.0001620001,0.000298535,0.9314693,0.0003921624,0.01060565,0.00002002489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568059,0.02909822,0.009117953,0.0006592597,0.000168643,0.00007473472,0.0005697185,0.0003431324,0.0031624],"genre_scores_gemma":[0.9807552,0.008052663,0.00452529,0.0002786973,0.00007452401,0.00003229527,0.0008057241,0.00003861129,0.005437157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009460359,"threshold_uncertainty_score":0.003164828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159094108126786,"score_gpt":0.2248715862588391,"score_spread":0.2132806451775712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}