{"id":"W4413803565","doi":"10.3389/fcimb.2025.1627518","title":"The RNA-binding protein ProQ directly binds and regulates virulence genes in enterohemorrhagic Escherichia coli O157:H7","year":2025,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Virulence; Biology; Escherichia coli; Microbiology; Gene; Transcriptional regulation; RNA; Pathogen; Regulation of gene expression; Regulator; Genetics; Gene expression; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346725,0.0002640747,0.0002284152,0.0001509519,0.0001547249,0.000241107,0.0001025326,0.0002320499,0.0006864998],"category_scores_gemma":[0.0001643538,0.0001335596,0.0001735842,0.00007616804,0.0002756079,0.000145084,0.0002452673,0.0003112176,0.0003927108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981302,"about_ca_system_score_gemma":0.0001190149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000490207,"about_ca_topic_score_gemma":0.0005899708,"domain_scores_codex":[0.9998324,0.00003121277,0.000007528377,0.00004454586,0.0000510143,0.00003328732],"domain_scores_gemma":[0.9998858,0.00003197161,0.00002530125,0.00001035826,0.00002373705,0.00002282743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002611623,0.000004605913,0.0001411285,0.00001100688,8.195215e-7,0.00002138056,0.000007430529,0.00001509806,0.9994073,0.0000175694,0.00001074088,0.0003368033],"study_design_scores_gemma":[0.000008514839,0.000284685,0.03277807,0.000008842986,0.000009383642,0.0002152285,0.0001225978,0.001611499,0.9631246,0.0001120354,0.001715041,0.000009610641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924498,0.002079129,0.004099696,0.0001205087,0.00002722444,0.00001076428,0.0001478241,0.00006816233,0.0009970035],"genre_scores_gemma":[0.9955229,0.0005223692,0.001726682,0.0001073669,0.00001151962,0.00001555607,0.0003275588,0.00002849653,0.001737529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006864998,"threshold_uncertainty_score":0.002296567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004827310332225601,"score_gpt":0.2257575542401777,"score_spread":0.2209302439079521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}