{"id":"W4413809199","doi":"10.1093/eurheartj/ehaf611","title":"Germline and somatic variants in <i>DNMT3A</i> and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Queen's University","funders":"National Heart, Lung, and Blood Institute; Norges Idrettshøgskole; Canada Foundation for Innovation; National Institutes of Health; Ontario Institute for Cancer Research; Canadian Vascular Network; Canadian Institutes of Health Research; JPB Foundation","keywords":"Germline; Somatic cell; Germline mutation; Medicine; Internal medicine; Cancer research; Genetics; Immunology; Gene; Biology; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138074,0.0002134451,0.0001555691,0.0004123116,0.0001541203,0.0002776892,0.0001462846,0.0002832326,0.002898748],"category_scores_gemma":[0.0007723799,0.00008654122,0.0001604209,0.0003409486,0.0002407278,0.0001245942,0.0002170457,0.0001831104,0.0001704156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001084015,"about_ca_system_score_gemma":0.00007197294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007542712,"about_ca_topic_score_gemma":0.0007794541,"domain_scores_codex":[0.9998332,0.00003270287,0.00002031222,0.00006171694,0.00003351874,0.000018547],"domain_scores_gemma":[0.9995887,0.0001261725,0.0001792841,0.00002924883,0.0000251392,0.00005148808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009343799,0.00003372943,0.8667681,0.00008435427,0.0002108556,0.0009736485,0.0001419292,0.0002435552,0.1156007,0.0002537144,0.0002002941,0.01455474],"study_design_scores_gemma":[0.00001441861,0.0001038765,0.9882721,0.00001605761,0.00009737828,0.004159636,0.00005219457,0.000454131,0.006225524,0.0001424538,0.0004583307,0.000003991317],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998626,0.0003189075,0.0003913744,0.00002404428,0.000002124074,0.00000341623,0.0002201141,0.00001030053,0.000403738],"genre_scores_gemma":[0.9994881,0.00008467188,0.0002101196,0.00001434704,0.000004110519,0.00000187681,0.0000867511,0.000002956074,0.0001069921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002898748,"threshold_uncertainty_score":0.009697318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588597053420089,"score_gpt":0.2943004790333595,"score_spread":0.2684145084991586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}