{"id":"W4413810249","doi":"10.1016/s2152-2650(25)01335-7","title":"POSTER: MM-1157 Trial in Progress: Quintessential—A Phase 2 Study of Arlocabtagene Autoleucel in Triple- and Quad-Class Exposed Patients With Relapsed and Refractory Multiple Myeloma","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Calgary","funders":"","keywords":"Medicine; Class (philosophy); Refractory (planetary science); Multiple myeloma; Oncology; Internal medicine; Artificial intelligence; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001954838,0.001818379,0.002175847,0.0004174183,0.0005523636,0.001744975,0.001335085,0.002042181,0.01293024],"category_scores_gemma":[0.001120206,0.0005541986,0.002441334,0.0003243851,0.001020608,0.001098912,0.0005978326,0.006389849,0.00242131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001081244,"about_ca_system_score_gemma":0.00151852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001841854,"about_ca_topic_score_gemma":0.004871052,"domain_scores_codex":[0.9994961,0.0002428383,0.00001928099,0.00007550939,0.00003809469,0.0001281062],"domain_scores_gemma":[0.9991997,0.0001126011,0.0001129786,0.0000539437,0.00003970783,0.0004811817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7329671,0.02110609,0.003406234,0.001463614,0.003823393,0.0002473506,0.0003098632,0.002783398,0.01642785,0.001486864,0.05336129,0.162617],"study_design_scores_gemma":[0.8411839,0.1364613,0.00731902,0.00009444623,0.0007523826,0.0001509193,0.0000542191,0.0009259073,0.001346158,0.0005492333,0.01110852,0.00005403852],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935312,0.0169091,0.002144315,0.01125222,0.002648761,0.004608486,0.0100941,0.001115493,0.01591559],"genre_scores_gemma":[0.9329342,0.007505166,0.004150615,0.01126754,0.001456296,0.003193316,0.01165333,0.0002451161,0.02759455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01293024,"threshold_uncertainty_score":0.04325598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02911607489570633,"score_gpt":0.3543912730620614,"score_spread":0.325275198166355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}