{"id":"W4413810439","doi":"10.1016/s2152-2650(25)02692-8","title":"MM-1157: Trial in Progress: Quintessential—A Phase 2 Study of Arlocabtagene Autoleucel in Triple- and Quad-Class Exposed Patients With Relapsed and Refractory Multiple Myeloma","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Calgary","funders":"","keywords":"Medicine; Multiple myeloma; Refractory (planetary science); Class (philosophy); Oncology; Lenalidomide; Internal medicine; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002355474,0.002110239,0.002618692,0.0006361703,0.0005054927,0.00188912,0.001875037,0.001801318,0.006341265],"category_scores_gemma":[0.001071908,0.0006166083,0.002478724,0.0005339615,0.001403527,0.001369873,0.0006766562,0.006404959,0.001461809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001250131,"about_ca_system_score_gemma":0.001784953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002659715,"about_ca_topic_score_gemma":0.006688227,"domain_scores_codex":[0.9993894,0.0002977269,0.00002112611,0.00008429758,0.00004573897,0.0001617359],"domain_scores_gemma":[0.9992344,0.000116588,0.0001171139,0.00005985588,0.00003390463,0.0004380793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7658272,0.03146273,0.005236106,0.001230057,0.003200032,0.0002538584,0.0004063847,0.003497225,0.01695786,0.001483712,0.01689436,0.1535505],"study_design_scores_gemma":[0.818339,0.1659129,0.007325273,0.00006657072,0.0006062883,0.0002096416,0.00008063035,0.001331173,0.001279892,0.0003856915,0.004410446,0.00005230215],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766743,0.007599574,0.00120103,0.002500332,0.0005487155,0.002188823,0.003551947,0.000655078,0.005080133],"genre_scores_gemma":[0.9678195,0.005585441,0.002910363,0.00354601,0.0004932487,0.002419269,0.008090467,0.0001506118,0.008985152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006341265,"threshold_uncertainty_score":0.02121371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03015537811308758,"score_gpt":0.3578107111767318,"score_spread":0.3276553330636442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}