{"id":"W4413812423","doi":"10.1016/j.immuni.2025.08.001","title":"Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity","year":2025,"lang":"en","type":"article","venue":"Immunity","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"European Research Council; University at Buffalo; Horizon 2020 Framework Programme; Novo Nordisk Fonden; Region Skåne; Vetenskapsrådet; Science for Life Laboratory; Lund University Medical Faculty Foundation; H2020 European Research Council; Cancerfonden; European Commission; Knut och Alice Wallenbergs Stiftelse; Lunds Universitet; Fundação para a Ciência e a Tecnologia; Francis Crick Institute; Cancer Research Institute","keywords":"Biology; Transcription factor; Immunity; Diversity (politics); Dendritic cell; Blueprint; Immunology; Cancer research; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940349,0.00025184,0.0002186636,0.000396497,0.00009517166,0.0003232707,0.0001491271,0.0001961828,0.0008627902],"category_scores_gemma":[0.0002501336,0.0001493659,0.0002083621,0.0002396994,0.0002005269,0.000142122,0.0002798991,0.0003322962,0.0003350794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168335,"about_ca_system_score_gemma":0.0001660768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001761044,"about_ca_topic_score_gemma":0.000524935,"domain_scores_codex":[0.9997634,0.0000296027,0.0000124253,0.00005200438,0.00008023516,0.00006233751],"domain_scores_gemma":[0.9998205,0.00004811247,0.00005175122,0.00002479382,0.00001999644,0.00003481865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003504248,0.000005042887,0.0003313154,0.000004877541,0.000001487397,0.00001941311,0.000004518294,0.00004835729,0.9984581,0.00003727145,0.000005221531,0.001049497],"study_design_scores_gemma":[0.000005528585,0.0002169616,0.006583704,0.00000278728,0.00001387222,0.0002201736,0.00003325859,0.00111697,0.9907589,0.0001022809,0.0009413872,0.00000428103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909889,0.0004864926,0.007126982,0.0000394726,0.000006092923,0.00003386438,0.0003274771,0.0001007076,0.0008900635],"genre_scores_gemma":[0.9946255,0.0003045702,0.003832047,0.00003743215,0.000003794423,0.00002009136,0.0004567224,0.00002297444,0.0006968324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008627902,"threshold_uncertainty_score":0.002886295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04489280934431482,"score_gpt":0.2653632007123182,"score_spread":0.2204703913680033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}