{"id":"W4413817119","doi":"10.3389/fonc.2025.1638405","title":"Comparing the safety and efficacy of systemic therapies for high-risk biochemically recurrent hormone-sensitive prostate cancer: a network meta-analysis","year":2025,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Astellas Foundation for Research on Metabolic Disorders; Astellas Pharma; Pfizer","keywords":"Prostate cancer; Medicine; Meta-analysis; Oncology; Cancer; Internal medicine; Prostate; Hormone therapy; Hormone; Bioinformatics; Biology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02154244,0.002704548,0.01238391,0.004094355,0.0004786033,0.002987217,0.002268355,0.00194798,0.003502621],"category_scores_gemma":[0.03674021,0.001318569,0.04917061,0.00416925,0.0006658686,0.001462597,0.001336119,0.002256459,0.0002864676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002096693,"about_ca_system_score_gemma":0.001847276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00859876,"about_ca_topic_score_gemma":0.01104375,"domain_scores_codex":[0.9813432,0.01360889,0.001956308,0.001809823,0.0009227366,0.000359022],"domain_scores_gemma":[0.9713273,0.02365603,0.002633924,0.001137706,0.0009382772,0.0003068339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004807268,0.00002917177,0.006638485,0.03850249,0.941856,0.00007090825,0.00003015193,0.002962627,0.0001948575,0.0001321536,0.0003824597,0.004393478],"study_design_scores_gemma":[0.001145871,0.0002668969,0.003856387,0.002385575,0.9901788,0.00004192912,0.00001431494,0.00115803,0.0001000035,0.0003061029,0.0005281001,0.00001792647],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06396129,0.9217275,0.006761894,0.001047694,0.0004881528,0.0008321854,0.003454769,0.0001871929,0.001539252],"genre_scores_gemma":[0.8468651,0.1403973,0.006705844,0.001124957,0.000280841,0.001450116,0.002470848,0.00009271457,0.0006122226],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02154244,"threshold_uncertainty_score":0.1139287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06996432049823002,"score_gpt":0.3893688567312548,"score_spread":0.3194045362330247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}