{"id":"W4413817817","doi":"10.1126/sciadv.adw0128","title":"Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Mental Health","keywords":"Neuroscience; Cytoskeleton; Biology; Microglia; Actin cytoskeleton; Neurotransmission; Synaptic plasticity; Cell biology; Immunology; Cell; Inflammation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087459,0.0003549353,0.0002111839,0.00022197,0.0002482438,0.0003688244,0.0002229497,0.000335811,0.0007273192],"category_scores_gemma":[0.0001109497,0.0001066928,0.0001417601,0.00009738676,0.0002761432,0.0001472159,0.0002182279,0.0003436366,0.0003064247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000457229,"about_ca_system_score_gemma":0.00046049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006124857,"about_ca_topic_score_gemma":0.001516183,"domain_scores_codex":[0.9998981,0.000008847277,0.000008045126,0.00001757995,0.00003382309,0.00003369775],"domain_scores_gemma":[0.9998956,0.000004627562,0.00004790674,0.00001132967,0.00001364621,0.0000270037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009717398,0.0000286103,0.0003673705,0.00004518054,0.000005278733,0.0001129979,0.00001564941,0.00009347849,0.9955036,0.0003209803,0.0001061624,0.003303635],"study_design_scores_gemma":[0.00004484198,0.000338805,0.01556265,0.00004802729,0.00004474523,0.000872773,0.0001111997,0.001272958,0.9698099,0.0005748261,0.01131064,0.0000086896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889227,0.004449674,0.002908848,0.0003509074,0.00006972061,0.00002375325,0.0003325391,0.0002392187,0.002702702],"genre_scores_gemma":[0.9935721,0.002275948,0.001805511,0.00006965197,0.00001845152,0.00002394696,0.0002030934,0.0000225918,0.002008646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007273192,"threshold_uncertainty_score":0.003317416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009233260629080111,"score_gpt":0.2791519798567018,"score_spread":0.2699187192276217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}