{"id":"W4413820632","doi":"10.1139/bcb-2025-0058","title":"Galanthamine promotes neuronal differentiation and neurite outgrowth of neural progenitor/stem cells by up-regulating IGF-2","year":2025,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Hunan Province; Scientific Research Foundation of Hunan Provincial Education Department; National Natural Science Foundation of China","keywords":"Neurite; Neural stem cell; Neuroscience; Progenitor cell; Cholinergic; Biology; Acetylcholinesterase; Stem cell; Cholinergic neuron; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004740194,0.0001991515,0.0002659953,0.00001650108,0.00006805544,0.00002042711,0.0001134721,0.0002260001,0.00006935827],"category_scores_gemma":[0.0000199833,0.0001750834,0.00005939901,0.00005561943,0.0001742361,0.00002096468,0.000125218,0.0001396605,3.484137e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001056051,"about_ca_system_score_gemma":0.00001646701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001078302,"about_ca_topic_score_gemma":2.484443e-7,"domain_scores_codex":[0.9990016,0.00001920347,0.0003038793,0.0004002561,0.00005846945,0.0002165972],"domain_scores_gemma":[0.9994658,0.0001320832,0.0001417053,0.0001585198,0.00003038948,0.00007153321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003984774,0.00007660212,0.01497666,0.0006257328,0.00001996461,2.458697e-7,0.0000157768,7.804512e-8,0.9768794,0.000009910325,0.0001649156,0.007190928],"study_design_scores_gemma":[0.0004218481,0.00002218767,0.0002250408,0.00004367116,0.000036723,0.000003178644,0.00004055548,0.0003871877,0.9981148,0.00004580278,0.0005075077,0.0001514747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966915,0.001879503,0.000006947954,0.00008690212,0.00006215638,0.00005259063,0.00009657081,0.00002975161,0.00109406],"genre_scores_gemma":[0.9980313,0.00008583313,0.00002255421,0.0000206428,0.00007803509,0.00001083469,0.00009818048,0.000009649804,0.001642961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02123548,"threshold_uncertainty_score":0.7139693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005817049282988931,"score_gpt":0.2016092746060397,"score_spread":0.1957922253230508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}