{"id":"W4413824227","doi":"10.1101/2025.08.27.672390","title":"Biomolecular phase boundaries are described by a solubility product that accounts for variable stoichiometry and soluble oligomers","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"nanoparticles nucleation surface interactions","field":"Earth and Planetary Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Solubility; Phase (matter); Stoichiometry; Phase boundary; Monomer; Thermodynamics; Curvature; Chemistry; Oligomer; Phase diagram; Boundary (topology); Biomolecule; Power law; Solubility equilibrium; Precipitation; Chemical physics; Materials science; Organic chemistry; Physics; Polymer; Mathematics; Mathematical analysis; Nanotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005325843,0.0007071862,0.0004177801,0.0006482836,0.000400051,0.0007763181,0.001010734,0.0008395819,0.001812014],"category_scores_gemma":[0.001213065,0.0004329725,0.0005672497,0.000332866,0.001027171,0.001958023,0.0006263141,0.00094692,0.0008825072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006596055,"about_ca_system_score_gemma":0.0005642833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007839455,"about_ca_topic_score_gemma":0.0005598541,"domain_scores_codex":[0.9996866,0.00003519092,0.00002160205,0.00006791812,0.000155145,0.00003361334],"domain_scores_gemma":[0.999645,0.0001339046,0.00008849321,0.00005598821,0.00006359567,0.00001289305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001076732,0.0001471004,0.003418045,0.000459186,0.00004884466,0.0007289721,0.0004204948,0.2713136,0.355399,0.3308957,0.002494064,0.03456733],"study_design_scores_gemma":[0.00001639054,0.0000722367,0.001131325,0.00002894861,0.00001212111,0.000388272,0.00004750708,0.7763909,0.1463199,0.06433576,0.01122306,0.00003359664],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1272407,0.0007858459,0.8513402,0.0001790307,0.0000766012,0.0001610201,0.0003819195,0.0005830045,0.01925164],"genre_scores_gemma":[0.8812553,0.001051269,0.1037553,0.0001583386,0.00004809416,0.0004375784,0.0006892098,0.0007316809,0.01187321],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001812014,"threshold_uncertainty_score":0.006061792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060383899727277,"score_gpt":0.2456889806196309,"score_spread":0.2250851416223582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}