{"id":"W4413834158","doi":"10.1002/mco2.70345","title":"Phytosphingosine Alleviates Cigarette Smoke‐Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4","year":2025,"lang":"en","type":"article","venue":"MedComm","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Pulmonary disease; Cigarette smoke; Senescence; Receptor; Medicine; Disease; Cell; Cancer research; Chemistry; Internal medicine; Biochemistry; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269247,0.0002293453,0.0002677551,0.00026255,0.000146114,0.0001681798,0.000134644,0.000244622,0.001150933],"category_scores_gemma":[0.00004840293,0.0000999368,0.0003016252,0.0001177029,0.0001856848,0.0001800066,0.0001911012,0.0006079453,0.0001660876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611406,"about_ca_system_score_gemma":0.0002014409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005164581,"about_ca_topic_score_gemma":0.001028931,"domain_scores_codex":[0.999943,0.000012627,0.000004238094,0.000009118778,0.00001232529,0.0000187173],"domain_scores_gemma":[0.9999701,0.000002582984,0.000008144756,0.000003410398,0.000005132607,0.00001075076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006159865,0.0001374164,0.0002308464,0.00008456143,0.00001266139,0.00003331721,0.0000128413,0.00006225467,0.9942569,0.00008437478,0.00008213455,0.004386661],"study_design_scores_gemma":[0.0002116998,0.003447746,0.01879366,0.00003266211,0.00009047527,0.0001920855,0.0000985498,0.002098201,0.968017,0.0002274125,0.006777351,0.00001312347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911494,0.004863283,0.001951104,0.0003068723,0.0000754926,0.00004939592,0.0002691696,0.0001096318,0.001225647],"genre_scores_gemma":[0.9942914,0.002166834,0.00115835,0.0001295051,0.00001419415,0.00003259675,0.0002126719,0.00001020878,0.001984176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001150933,"threshold_uncertainty_score":0.003850281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006916172764756015,"score_gpt":0.2275252957321175,"score_spread":0.2206091229673615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}