{"id":"W4413834158","doi":"10.1002/mco2.70345","title":"Phytosphingosine Alleviates Cigarette Smoke‐Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4","year":2025,"lang":"en","type":"article","venue":"MedComm","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Pulmonary disease; Cigarette smoke; Senescence; Receptor; Medicine; Disease; Cell; Cancer research; Chemistry; Internal medicine; Biochemistry; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002040808,0.0002996542,0.0002454376,0.00003499391,0.0001780079,0.00003615876,0.000747792,0.000159373,0.00003094317],"category_scores_gemma":[0.0002374123,0.0002524181,0.0001321704,0.0001434757,0.0001928468,0.00000977455,0.0004713737,0.0003264801,0.00000434714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150308,"about_ca_system_score_gemma":0.0001786148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008728149,"about_ca_topic_score_gemma":0.00004655254,"domain_scores_codex":[0.9983167,0.0001586498,0.0003330479,0.0005922859,0.0001527526,0.0004465876],"domain_scores_gemma":[0.9989802,0.00004763856,0.0001368675,0.000653988,0.00007137489,0.0001099197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001759665,0.00008558495,0.009996795,0.00005523684,0.00003315056,0.000002839962,0.00008094197,0.00002330641,0.9842641,0.00001333677,0.003823388,0.001445378],"study_design_scores_gemma":[0.0007012069,0.00004337923,0.02237604,0.00004763378,0.00002481849,4.987406e-7,0.000125456,0.00009350347,0.9686542,0.0003181792,0.007334314,0.0002807647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904414,0.006175479,0.0004180085,0.001314888,0.0004318785,0.0003873097,0.0002630973,0.00001854946,0.0005493236],"genre_scores_gemma":[0.9977204,0.0002923942,0.0001944128,0.0004957062,0.0005419027,0.00007910934,0.000439546,0.00002870319,0.0002078791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01560987,"threshold_uncertainty_score":0.9999928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006916172764756015,"score_gpt":0.2275252957321175,"score_spread":0.2206091229673615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}