{"id":"W4413840361","doi":"10.1161/circulationaha.125.076575","title":"Dapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Glucose Cotransporter-2 Inhibitors in Patients Hospitalized for Heart Failure","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Michael's Hospital; Université de Montréal; St. Paul's Hospital; Montreal Heart Institute","funders":"Janssen Research and Development; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; American Regent; Intas Pharmaceuticals; Institut de Cardiologie de Montréal; Daiichi Sankyo Europe; Servier; Deutsche Herzstiftung; Novo Nordisk; Daiichi-Sankyo; Deutsche Forschungsgemeinschaft; Medicines Company; ARCA Biopharma; Zora Biosciences; National Center for Advancing Translational Sciences; Verily Life Sciences; AstraZeneca; Amarin Corporation; Sanofi; Abiomed; Ionis Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; Defense Acquisition Program Administration; Boston Scientific Corporation; Alnylam Pharmaceuticals; Duke Clinical Research Institute; Cytokinetics; Medpace; Brigham and Women's Hospital; Kowa Company; HLS Therapeutics; GlaxoSmithKline; Deutsches Zentrum für Herz-Kreislaufforschung; Harvard Catalyst; University of Glasgow; iRhythm Technologies; Amgen; Pfizer; Eli Lilly and Company","keywords":"Dapagliflozin; Medicine; Heart failure; TIMI; Randomized controlled trial; Internal medicine; Clinical trial; Cardiology; Pharmacology; Diabetes mellitus; Endocrinology; Type 2 diabetes; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008976448,0.002041937,0.009190498,0.001558061,0.0003760841,0.001926503,0.001106711,0.001763509,0.002941724],"category_scores_gemma":[0.01077003,0.0009667599,0.02126515,0.001511132,0.0004760512,0.0007979293,0.0006764753,0.001771618,0.0002646486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009948338,"about_ca_system_score_gemma":0.0006820026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002500747,"about_ca_topic_score_gemma":0.003333298,"domain_scores_codex":[0.994634,0.003354161,0.0006787656,0.000802302,0.0003508145,0.000179868],"domain_scores_gemma":[0.9948718,0.003142197,0.001122392,0.0004063365,0.000282609,0.000174655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.2161076,0.0002199139,0.01454637,0.02255942,0.7316737,0.000126065,0.00004782479,0.001484362,0.0007230283,0.0001282411,0.001129044,0.01125451],"study_design_scores_gemma":[0.06572808,0.002149885,0.01173401,0.0007934467,0.9169974,0.00007196283,0.0000197525,0.001270058,0.0002327182,0.0002595753,0.000716725,0.0000263956],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4355737,0.5491761,0.003632739,0.001455212,0.00161541,0.001288031,0.004556734,0.0003017194,0.002400258],"genre_scores_gemma":[0.9661918,0.02751448,0.001764063,0.0009553392,0.0005358149,0.000833121,0.001628054,0.00003684027,0.0005403862],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009190498,"threshold_uncertainty_score":0.04747254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334128332922098,"score_gpt":0.2984446364620538,"score_spread":0.2751033531328329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}