{"id":"W4413842901","doi":"10.1002/mds.70026","title":"Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Clinical Center; Universität Rostock; Leibniz-Gemeinschaft; Universitätsklinikum Köln; Deutschen Konsortium für Translationale Krebsforschung; Servier; Centre Hospitalier Universitaire de Bordeaux; Universität Ulm; Rheinische Friedrich-Wilhelms-Universität Bonn; Humboldt-Universität zu Berlin; Ludwig-Maximilians-Universität München; Universidad de Navarra; Eisai; University of Toronto; Deutsches Krebsforschungszentrum; Korea University; Johns Hopkins University; Eberhard Karls Universität Tübingen; University College London; Institute for Translational Neuroscience; Universität zu Köln; University of Ottawa; Imperial College London; Deutsche Forschungsgemeinschaft; Ochsner Health; Teva Pharmaceutical Industries; Korea University Guro Hospital; Rush University; Volkswagen Foundation; Pennsylvania State University; Technische Universität München; Ministero della Salute; Forschungszentrum Jülich; Biogen; Pfizer; H. Lundbeck A/S; Freie Universität Berlin; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universidade de Aveiro; University of Pennsylvania; School of Public Health, Imperial College London; Technische Universität Dresden; Sanofi; Bayer Vital; Bristol-Myers Squibb","keywords":"Progressive supranuclear palsy; Atrophy; Medicine; Neuroscience; Physical medicine and rehabilitation; Degenerative disease; Psychology; Central nervous system disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007979426,0.000591021,0.0007990447,0.0006356,0.0002484775,0.001032017,0.0004596636,0.00047624,0.001916407],"category_scores_gemma":[0.01274747,0.0003392593,0.0009443455,0.0003856464,0.0004115178,0.0008189837,0.0005135723,0.0007610378,0.0004258817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000308488,"about_ca_system_score_gemma":0.0006707014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002202485,"about_ca_topic_score_gemma":0.003209112,"domain_scores_codex":[0.9978352,0.001474709,0.0001587352,0.0002706232,0.0001947368,0.0000660503],"domain_scores_gemma":[0.9908085,0.00505281,0.002509723,0.0007384855,0.0005416485,0.0003487851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00535508,0.0002628055,0.9590278,0.0001827759,0.002009404,0.00008671219,0.00007151112,0.004305941,0.0008823879,0.0001523109,0.0006552514,0.02700799],"study_design_scores_gemma":[0.0003866975,0.004787145,0.9519567,0.0002171043,0.001287985,0.0004021582,0.0001168574,0.0371874,0.0009078952,0.001953957,0.0007694001,0.00002663786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929842,0.00222687,0.002038102,0.0002870219,0.00002911635,0.00004388926,0.0008229411,0.00005666892,0.001511178],"genre_scores_gemma":[0.9989366,0.0001336187,0.0003308621,0.00004912927,0.00001118017,0.00001071841,0.0003732274,0.000004188464,0.000150377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007979426,"threshold_uncertainty_score":0.04219973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118181123571047,"score_gpt":0.3321218090939432,"score_spread":0.3203036967368385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}