{"id":"W4413843359","doi":"10.1038/s41419-025-07980-8","title":"Targeting DDX3X suppresses progression of KRAS-driven lung cancer by disrupting antioxidative homeostasis and inducing ferroptosis","year":2025,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Sun Yat-sen University Cancer Center; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College; Canadian Institutes of Health Research; Peking Union Medical College; Nanfang Hospital; Peking Union Medical College Hospital; Southern Medical University; China Academy of Chinese Medical Sciences; OeAD-GmbH; National Natural Science Foundation of China; Sun Yat-sen University; CIHR Skin Research Training Centre; Bundesministerium für Bildung, Wissenschaft und Forschung; Cancer Research Institute; Österreichischen Akademie der Wissenschaften; Government of Canada","keywords":"KRAS; Homeostasis; Cancer research; Lung cancer; Biology; Cancer; Cell biology; Medicine; Internal medicine; Colorectal cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004554625,0.0001043861,0.0001041765,0.00003213098,0.0001332423,0.00002905579,0.00005766064,0.00004961678,0.00001127746],"category_scores_gemma":[0.00006443648,0.00009182593,0.00002873628,0.00006949677,0.0000591389,0.000008610758,0.00008886221,0.00004075089,8.134805e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008036677,"about_ca_system_score_gemma":0.00009030865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003999879,"about_ca_topic_score_gemma":0.000001502917,"domain_scores_codex":[0.9993631,0.00003045166,0.0001337472,0.0002781563,0.00005852071,0.0001360434],"domain_scores_gemma":[0.999588,0.00001373036,0.00007599187,0.0001305712,0.00006145376,0.000130217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191935,0.00009150815,0.2585218,0.0004286768,0.00004590467,0.000001134568,0.0001093716,0.00007870107,0.7235169,0.00004423899,0.002922666,0.01411983],"study_design_scores_gemma":[0.00197293,0.0001354162,0.09038395,0.0006118034,0.0004514625,5.768194e-7,0.0009951837,0.004901253,0.8911196,0.0001032568,0.008703224,0.0006213471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446531,0.05365546,0.0009988982,0.0001194206,0.00003435632,0.0001649757,0.0001591561,0.000005802226,0.0002088228],"genre_scores_gemma":[0.9918453,0.007389351,0.0002996444,0.00006978023,0.0000287631,0.000056665,0.0001363804,0.000008320234,0.0001658011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1681379,"threshold_uncertainty_score":0.3744553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006792340760677853,"score_gpt":0.2929295038768288,"score_spread":0.2861371631161509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}