{"id":"W4413843359","doi":"10.1038/s41419-025-07980-8","title":"Targeting DDX3X suppresses progression of KRAS-driven lung cancer by disrupting antioxidative homeostasis and inducing ferroptosis","year":2025,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Sun Yat-sen University Cancer Center; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College; Canadian Institutes of Health Research; Peking Union Medical College; Nanfang Hospital; Peking Union Medical College Hospital; Southern Medical University; China Academy of Chinese Medical Sciences; OeAD-GmbH; National Natural Science Foundation of China; Sun Yat-sen University; CIHR Skin Research Training Centre; Bundesministerium für Bildung, Wissenschaft und Forschung; Cancer Research Institute; Österreichischen Akademie der Wissenschaften; Government of Canada","keywords":"KRAS; Homeostasis; Cancer research; Lung cancer; Biology; Cancer; Cell biology; Medicine; Internal medicine; Colorectal cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206912,0.0002930678,0.0002301163,0.0001338066,0.0001039857,0.0001764257,0.0001324406,0.0002061098,0.0008370765],"category_scores_gemma":[0.00005027012,0.00007416699,0.0001608167,0.00008952358,0.00016698,0.0001014365,0.0001160588,0.0003787213,0.0001789476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112342,"about_ca_system_score_gemma":0.0002129954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003822349,"about_ca_topic_score_gemma":0.0008205156,"domain_scores_codex":[0.9999353,0.000009861327,0.000007699648,0.00001140011,0.00001893313,0.0000168064],"domain_scores_gemma":[0.9999543,0.00000612027,0.0000159371,0.000004795396,0.000004829888,0.00001385148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001895773,0.00004884644,0.0001357835,0.0000351368,0.000004589318,0.00002136348,0.000005775479,0.00006037871,0.998072,0.00003983363,0.00004211055,0.001344487],"study_design_scores_gemma":[0.00002806224,0.0006724749,0.001330161,0.000002378977,0.000008247727,0.0001128167,0.000008601728,0.0005226679,0.9958413,0.00001824078,0.001453223,0.000001791448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942059,0.001729237,0.002677649,0.0001084577,0.00003484914,0.00004313062,0.0002947642,0.0001514861,0.0007545201],"genre_scores_gemma":[0.9946188,0.0007530934,0.001803439,0.00004532431,0.000006344295,0.00003459956,0.0003230195,0.00001664206,0.002398653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008370765,"threshold_uncertainty_score":0.002800345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006792340760677853,"score_gpt":0.2929295038768288,"score_spread":0.2861371631161509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}