{"id":"W4413859329","doi":"10.1093/neuonc/noaf140","title":"Preanalytical variables and analytes in liquid biopsy approach for brain tumors: A comprehensive review and recommendations from the RANO Group and the Brain Liquid Biopsy Consortium","year":2025,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University","funders":"University of California, San Francisco; University of Texas MD Anderson Cancer Center; Medac; Daiichi Sankyo Europe; National Cancer Institute; Servier; Universitat Autònoma de Barcelona; Università degli Studi di Torino; Universität Zürich; Umeå Universitet; Bar-Ilan University; McGill University; University of Leeds; ViewRay; Moffitt Cancer Center; Apollomics; Sidney Kimmel Comprehensive Cancer Center; Pfizer; Incyte; AstraZeneca; Novocure; Cancer Research UK; Boston Scientific Corporation; Karyopharm Therapeutics; Wayne State University; University of Illinois at Urbana-Champaign; Michigan State University; Amgen; College of Engineering, Michigan State University; Johns Hopkins University; Henry Ford Health System; Vrije Universiteit Amsterdam; Focused Ultrasound Foundation; University of Sussex; Alexion Pharmaceuticals; Eli Lilly and Company","keywords":"Liquid biopsy; Biopsy; Brain biopsy; Analyte; Medicine; Brain tumor; Medical physics; Pathology; Internal medicine; Chemistry; Chromatography; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0038719,0.001007503,0.002005992,0.003884004,0.0003304119,0.001632114,0.001468319,0.001587366,0.002452502],"category_scores_gemma":[0.004932918,0.0004110803,0.001570001,0.002447513,0.0007275757,0.001644636,0.0009864785,0.002016159,0.001552561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001014135,"about_ca_system_score_gemma":0.003354797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002097535,"about_ca_topic_score_gemma":0.003421118,"domain_scores_codex":[0.9989078,0.000300256,0.0002484177,0.0001508597,0.0003354524,0.00005717669],"domain_scores_gemma":[0.9968099,0.002110534,0.0002769584,0.00006452284,0.0006724626,0.00006554704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001140557,0.00005764553,0.0005027935,0.03078337,0.0002336141,0.0002421906,0.0000933695,0.0003174198,0.001108585,0.002578597,0.02009096,0.9438773],"study_design_scores_gemma":[0.00003188092,0.000165278,0.00171259,0.02399199,0.000801401,0.001753469,0.0001397816,0.0001967299,0.001733379,0.002624047,0.9667882,0.00006119535],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001044818,0.998131,0.0004027991,0.0006589495,0.00016809,0.0000135073,0.00003629367,0.00001065144,0.0004741207],"genre_scores_gemma":[0.0006624474,0.9974325,0.0009086108,0.0004620925,0.0001382995,0.00002410127,0.00007924953,0.000005176592,0.000287495],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003884004,"threshold_uncertainty_score":0.02047682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261806576509487,"score_gpt":0.3238853874818349,"score_spread":0.2977047298308862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}