{"id":"W4413859329","doi":"10.1093/neuonc/noaf140","title":"Preanalytical variables and analytes in liquid biopsy approach for brain tumors: A comprehensive review and recommendations from the RANO Group and the Brain Liquid Biopsy Consortium","year":2025,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University","funders":"University of California, San Francisco; University of Texas MD Anderson Cancer Center; Medac; Daiichi Sankyo Europe; National Cancer Institute; Servier; Universitat Autònoma de Barcelona; Università degli Studi di Torino; Universität Zürich; Umeå Universitet; Bar-Ilan University; McGill University; University of Leeds; ViewRay; Moffitt Cancer Center; Apollomics; Sidney Kimmel Comprehensive Cancer Center; Pfizer; Incyte; AstraZeneca; Novocure; Cancer Research UK; Boston Scientific Corporation; Karyopharm Therapeutics; Wayne State University; University of Illinois at Urbana-Champaign; Michigan State University; Amgen; College of Engineering, Michigan State University; Johns Hopkins University; Henry Ford Health System; Vrije Universiteit Amsterdam; Focused Ultrasound Foundation; University of Sussex; Alexion Pharmaceuticals; Eli Lilly and Company","keywords":"Liquid biopsy; Biopsy; Brain biopsy; Analyte; Medicine; Brain tumor; Medical physics; Pathology; Internal medicine; Chemistry; Chromatography; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000898156,0.0004475087,0.001722743,0.00008988384,0.0001730039,0.00006749038,0.000346139,0.0004212287,0.000009359257],"category_scores_gemma":[0.002356713,0.0002915779,0.0002338574,0.0002455884,0.0007148979,0.000005221905,0.0005743951,0.0003943531,4.176147e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004080502,"about_ca_system_score_gemma":0.0004824837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001167997,"about_ca_topic_score_gemma":0.00008851627,"domain_scores_codex":[0.9967166,0.001175125,0.0008093098,0.0008975035,0.00006972586,0.0003317785],"domain_scores_gemma":[0.9907649,0.008107935,0.0003881199,0.0005455908,0.00008661613,0.0001069012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006827362,0.001354529,0.0001028646,0.07620512,0.004908526,0.0001173735,0.0007524039,0.00001577459,0.01039734,0.03515499,0.2305638,0.6335999],"study_design_scores_gemma":[0.001680197,0.0006755739,0.000005213722,0.001607313,0.001582277,0.0002193001,0.00006403823,0.00006702216,0.0000138645,0.0001720711,0.9936202,0.0002929539],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001420789,0.9833896,0.001111137,0.01116457,0.000131767,0.002763354,0.001049123,0.000008309711,0.0002400185],"genre_scores_gemma":[0.00006052551,0.9858508,0.001442149,0.01019999,0.0002396545,0.0008035138,0.001338486,0.00003755282,0.00002739052],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7630564,"threshold_uncertainty_score":0.9999536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261806576509487,"score_gpt":0.3238853874818349,"score_spread":0.2977047298308862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}