{"id":"W4413862400","doi":"10.2196/76105","title":"Acute Adenosine Receptor Antagonism in Combination With Acute Intermittent Hypoxia to Promote Breathing Plasticity in Amyotrophic Lateral Sclerosis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled Trial","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Neuroscience of respiration and sleep","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute","keywords":"Medicine; Hypoxia (environmental); Randomized controlled trial; Amyotrophic lateral sclerosis; Adenosine; Placebo; Anesthesia; Adenosine receptor; Pharmacology; Physical medicine and rehabilitation; Internal medicine; Receptor; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01254857,0.007048381,0.01372918,0.002065305,0.003597931,0.003285151,0.004125097,0.007540294,0.03993406],"category_scores_gemma":[0.01197733,0.002927792,0.004693961,0.002203141,0.003429619,0.002843384,0.001857457,0.007826601,0.008760344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003136328,"about_ca_system_score_gemma":0.009638918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002343921,"about_ca_topic_score_gemma":0.004617477,"domain_scores_codex":[0.9923391,0.003306893,0.0009292457,0.001240327,0.0008761383,0.001308315],"domain_scores_gemma":[0.9936717,0.001161847,0.001358757,0.0009030603,0.001426651,0.001477963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9679997,0.01502733,0.0001465814,0.00298223,0.001063184,0.0000746129,0.0000614525,0.000490075,0.002065093,0.0004903018,0.002445179,0.007154305],"study_design_scores_gemma":[0.9687001,0.02530507,0.0004110329,0.0002688745,0.0003767534,0.00001579114,0.00001947702,0.0003548424,0.0003103987,0.0004326516,0.003770872,0.00003399186],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01332435,0.000867488,0.001832458,0.0003867309,0.001159088,0.9795861,0.001335015,0.0002372992,0.001271388],"genre_scores_gemma":[0.01058959,0.0004059663,0.0020904,0.0003652846,0.0002288176,0.9849091,0.0002323217,0.00001402033,0.001164323],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03993406,"threshold_uncertainty_score":0.1335928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1524229754624118,"score_gpt":0.466736491025555,"score_spread":0.3143135155631432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}