{"id":"W4413869842","doi":"10.1016/j.modpat.2025.100878","title":"Cross-Platform Methylation-Based Site of Origin Classification for Squamous Cell Carcinomas","year":2025,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University Health Network; BC Children's Hospital; Princess Margaret Cancer Centre; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Vancouver Coastal Health Research Institute; Genome British Columbia; Terry Fox Research Institute; Canada Foundation for Innovation; Genome Canada","keywords":"Methylation; Pathology; Basal cell; Medicine; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001449685,0.0006738594,0.0006495565,0.001638958,0.0003649006,0.0006055081,0.0005370106,0.0005816433,0.001993637],"category_scores_gemma":[0.00367781,0.0002207911,0.000640101,0.0004105604,0.0001753201,0.0004978696,0.0011091,0.0005649331,0.0009487307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002923546,"about_ca_system_score_gemma":0.0004065824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002063814,"about_ca_topic_score_gemma":0.005228931,"domain_scores_codex":[0.9992861,0.000132688,0.00008280643,0.0002564063,0.0001478042,0.00009414551],"domain_scores_gemma":[0.9988163,0.0004082108,0.0001771302,0.0001685032,0.0003171284,0.0001127893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002161568,0.0003237364,0.5851607,0.0004241465,0.0009309984,0.0006210119,0.0003147805,0.02016668,0.09876796,0.0005703223,0.009337014,0.281221],"study_design_scores_gemma":[0.0001918007,0.001392996,0.2888665,0.0002056752,0.000653824,0.002423829,0.0003968621,0.5627414,0.1266705,0.003661973,0.01263591,0.0001587605],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489607,0.001951103,0.03800778,0.0002682479,0.0001241449,0.0002640135,0.005107883,0.001860023,0.003456226],"genre_scores_gemma":[0.9708156,0.0002341785,0.02148325,0.0001533171,0.00006170254,0.000130398,0.005726643,0.00007300782,0.001321813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002063814,"threshold_uncertainty_score":0.007666767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04556456077633543,"score_gpt":0.3451416777848371,"score_spread":0.2995771170085016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}