{"id":"W4413871093","doi":"10.1016/j.jaad.2025.05.968","title":"63305 Long-term efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata (AA): 3-year results from the ALLEGRO-LT phase 3, open-label study","year":2025,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Alopecia areata; Dermatology; Open label; Term (time); Pediatrics; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001089961,0.0005624171,0.001743568,0.0002183001,0.0003197497,0.0006976507,0.0003449401,0.0007989369,0.001819921],"category_scores_gemma":[0.0005663057,0.0002316378,0.001428785,0.0002505556,0.0003943667,0.0006878951,0.0001735375,0.001677132,0.0007841886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004134589,"about_ca_system_score_gemma":0.0005035049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007220409,"about_ca_topic_score_gemma":0.002281159,"domain_scores_codex":[0.9996668,0.0001175641,0.00002669967,0.00005347799,0.00005605718,0.00007946737],"domain_scores_gemma":[0.9995375,0.0001341407,0.0001200438,0.0000301569,0.00003637408,0.0001419812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4480549,0.02366882,0.04371962,0.002608794,0.005375367,0.0006327978,0.0004009069,0.002952125,0.03359905,0.0003726363,0.009647079,0.4289679],"study_design_scores_gemma":[0.3307086,0.3924562,0.2518711,0.0003207434,0.003828607,0.001632505,0.0002575866,0.003408788,0.004873197,0.000340516,0.01017813,0.0001241363],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986446,0.01042054,0.0002389013,0.0002452433,0.00007340968,0.0002077761,0.0007740519,0.00009601621,0.001498119],"genre_scores_gemma":[0.9933513,0.003058618,0.000391119,0.0005532774,0.0001056949,0.0001882545,0.00120625,0.00001348309,0.001132056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001819921,"threshold_uncertainty_score":0.006088197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870791245709116,"score_gpt":0.3404769568733992,"score_spread":0.3217690444163081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}