{"id":"W4413874697","doi":"10.1038/s41590-025-02265-w","title":"Pre-TCR-targeted immunotherapy for T cell acute lymphoblastic leukemia","year":2025,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centro Nacional de Biotecnología; Agencia Estatal de Investigación; Brigham and Women's Hospital; University of Toronto; Ministerio de Ciencia, Innovación y Universidades; Universiteit van Amsterdam; European Commission; European Regional Development Fund; Centro de Biología Molecular Severo Ochoa; Comunidad de Madrid; Sunnybrook Research Institute; Fundación Inocente, Inocente; Fundación Ramón Areces","keywords":"T-cell receptor; Immunotherapy; Lymphoblastic Leukemia; T cell; Immunology; Medicine; Cancer research; Leukemia; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362257,0.0002694244,0.0001573887,0.0002225209,0.00009327989,0.0002665805,0.0001410097,0.0002654813,0.001190411],"category_scores_gemma":[0.0000888533,0.00008100278,0.0001456783,0.000123213,0.0001402424,0.0001984088,0.0001720115,0.0007277695,0.0005541505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552027,"about_ca_system_score_gemma":0.0001935912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001398393,"about_ca_topic_score_gemma":0.000258186,"domain_scores_codex":[0.9999101,0.00002045893,0.000005032513,0.00001069553,0.00003391507,0.00001977649],"domain_scores_gemma":[0.9999646,0.000006762765,0.000009698195,0.000004962924,0.000003925752,0.0000101309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004071461,0.0003808471,0.0005563057,0.0002560203,0.00001882644,0.0002396276,0.00003672304,0.0006719934,0.9055679,0.002198154,0.002333673,0.08733277],"study_design_scores_gemma":[0.0003610564,0.005956281,0.005664311,0.00005810128,0.0001002811,0.005354844,0.00004074127,0.004136652,0.8486823,0.00158569,0.1280442,0.00001557735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8643507,0.07897282,0.02563861,0.002765804,0.0008881469,0.0004725654,0.0002715763,0.001001608,0.0256381],"genre_scores_gemma":[0.9582311,0.02683187,0.006957125,0.000560973,0.0001753858,0.00008994658,0.0002338427,0.00003084528,0.006888822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190411,"threshold_uncertainty_score":0.003982365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004988481963432424,"score_gpt":0.289404259022559,"score_spread":0.2844157770591266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}