{"id":"W4413877962","doi":"10.3899/jrheum.2025-0671","title":"Discovery and Clinical Validation of C1M and C4M as Soluble Biomarkers for Diagnosis, Prognosis, and Symptom Prediction in Psoriatic Disease and Other Inflammatory Arthropathies","year":2025,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Psoriatic arthritis; Psoriasis; Biomarker; Disease; Clinical trial; Rheumatoid arthritis; Biomarker discovery; Internal medicine; Oncology; Dermatology; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01272618,0.0007558189,0.00108262,0.002349991,0.0004674893,0.002370083,0.0004702561,0.001294491,0.0009575325],"category_scores_gemma":[0.01500511,0.0002353157,0.0006846495,0.00104691,0.0006924852,0.001073114,0.0009360331,0.001131674,0.0003631385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008091215,"about_ca_system_score_gemma":0.001333117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007711778,"about_ca_topic_score_gemma":0.001317281,"domain_scores_codex":[0.9960079,0.001674151,0.0006924169,0.0003050586,0.001106598,0.0002137531],"domain_scores_gemma":[0.9910909,0.004547124,0.001490425,0.0003032868,0.002235064,0.0003331293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004609062,0.0003426079,0.1330853,0.004519355,0.001464279,0.0007961471,0.0003580097,0.001088654,0.01989065,0.00278451,0.01317453,0.8178869],"study_design_scores_gemma":[0.001656308,0.01669723,0.5003169,0.01233779,0.005975532,0.01319624,0.001209609,0.009795034,0.08608785,0.01312352,0.3389754,0.0006285413],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1623101,0.8017568,0.009005379,0.01816317,0.002239219,0.0003284896,0.0008033506,0.0000962218,0.005297211],"genre_scores_gemma":[0.6951138,0.2524395,0.03434345,0.006588086,0.00605674,0.0004188615,0.002298672,0.00004390906,0.002696914],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01272618,"threshold_uncertainty_score":0.06730324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338404125058467,"score_gpt":0.3021091488623624,"score_spread":0.2887251076117777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}