{"id":"W4413878219","doi":"10.1002/hbm.70336","title":"Lifespan Tree of Brain Anatomy: Diagnostic Values for Motor and Cognitive Neurodegenerative Diseases","year":2025,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Center for Advancing Translational Sciences; Medical Research Council; University of California, San Diego; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; U.S. Food and Drug Administration; National Institutes of Health; Grand Équipement National De Calcul Intensif; Stavros Niarchos Foundation; Pfizer; Child Mind Institute; Ministerio de Ciencia, Innovación y Universidades; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; Medpace; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; National Institute of Neurological Disorders and Stroke; University of Calgary; University of Cambridge; Leon Levy Foundation; Eisai; Cincinnati Children's Hospital Medical Center; Agence Nationale de la Recherche; F. Hoffmann-La Roche; Directorate for Biological Sciences; GlaxoSmithKline; Bristol-Myers Squibb; Université de Bordeaux; Eli Lilly and Company; National Health and Medical Research Council; AstraZeneca; University of California, San Francisco; Alzheimer's Society; National Institute of Child Health and Human Development; Synarc; Engineering and Physical Sciences Research Council; Dana Foundation; University of Southern California; Elan; Novartis; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroscience; Brain anatomy; Cognition; Psychology; Medicine; Physical medicine and rehabilitation; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00130455,0.0005050833,0.0004648507,0.002680643,0.0003080528,0.0006551725,0.0004416588,0.0006352911,0.001526213],"category_scores_gemma":[0.005085407,0.0001523646,0.0006339744,0.0008612851,0.0003461941,0.0008027798,0.0008997078,0.000519007,0.0004611252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004259877,"about_ca_system_score_gemma":0.000537914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002272877,"about_ca_topic_score_gemma":0.003355818,"domain_scores_codex":[0.9996244,0.0001186414,0.00003408976,0.0001053138,0.00007971994,0.00003789524],"domain_scores_gemma":[0.9981896,0.0007404793,0.0003609158,0.0002137707,0.0003335269,0.0001616878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0009744141,0.0002095828,0.4233221,0.0003845103,0.0004441013,0.001502407,0.0004202585,0.07279355,0.02960422,0.0081552,0.009462379,0.4527272],"study_design_scores_gemma":[0.00005363529,0.0003760457,0.262176,0.0002027913,0.0002189074,0.005082889,0.0003281166,0.6667723,0.01225862,0.04304811,0.009381342,0.0001013109],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6641331,0.00284143,0.3178112,0.001063044,0.000119965,0.0001647065,0.006597683,0.001530005,0.005738838],"genre_scores_gemma":[0.9316538,0.0004551347,0.06468861,0.00007955734,0.00006119117,0.00004958528,0.002508117,0.0000489606,0.000455047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002680643,"threshold_uncertainty_score":0.006899238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600187811273083,"score_gpt":0.2905377889825651,"score_spread":0.2745359108698343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}