{"id":"W4413878219","doi":"10.1002/hbm.70336","title":"Lifespan Tree of Brain Anatomy: Diagnostic Values for Motor and Cognitive Neurodegenerative Diseases","year":2025,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Center for Advancing Translational Sciences; Medical Research Council; University of California, San Diego; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; U.S. Food and Drug Administration; National Institutes of Health; Grand Équipement National De Calcul Intensif; Stavros Niarchos Foundation; Pfizer; Child Mind Institute; Ministerio de Ciencia, Innovación y Universidades; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; Medpace; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; National Institute of Neurological Disorders and Stroke; University of Calgary; University of Cambridge; Leon Levy Foundation; Eisai; Cincinnati Children's Hospital Medical Center; Agence Nationale de la Recherche; F. Hoffmann-La Roche; Directorate for Biological Sciences; GlaxoSmithKline; Bristol-Myers Squibb; Université de Bordeaux; Eli Lilly and Company; National Health and Medical Research Council; AstraZeneca; University of California, San Francisco; Alzheimer's Society; National Institute of Child Health and Human Development; Synarc; Engineering and Physical Sciences Research Council; Dana Foundation; University of Southern California; Elan; Novartis; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroscience; Brain anatomy; Cognition; Psychology; Medicine; Physical medicine and rehabilitation; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001164607,0.0001293772,0.0001836569,0.00009818069,0.0001657314,0.00001751365,0.00007493085,0.000088615,0.00001470832],"category_scores_gemma":[0.002425654,0.0001319438,0.00008045846,0.00007193755,0.0001423563,0.000003608563,0.00007296333,0.00004843905,7.17081e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004225858,"about_ca_system_score_gemma":0.00004744028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005529597,"about_ca_topic_score_gemma":0.00002491224,"domain_scores_codex":[0.9991303,0.0001455355,0.0001895601,0.000338624,0.00004514501,0.0001508335],"domain_scores_gemma":[0.999073,0.0005596046,0.00007560437,0.0001397986,0.00009943567,0.00005250898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001288236,0.00005643807,0.006512586,0.0001073347,0.0000988984,0.000002547396,0.000211748,0.000005062638,0.9694722,0.003114632,0.01813447,0.002155236],"study_design_scores_gemma":[0.01238834,0.004025667,0.6011482,0.0008012609,0.0005151278,0.00002061116,0.003151998,0.0007728916,0.2103872,0.01694194,0.1483451,0.001501651],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543902,0.001424921,0.04049873,0.001573184,0.0003105622,0.000743066,0.0002012012,0.00002174905,0.0008363479],"genre_scores_gemma":[0.9922503,0.00002664847,0.0003501869,0.002846772,0.0002960289,0.0001198015,0.0002639288,0.00001487501,0.003831462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.759085,"threshold_uncertainty_score":0.5380513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600187811273083,"score_gpt":0.2905377889825651,"score_spread":0.2745359108698343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}