{"id":"W4413880037","doi":"10.1242/dev.204425","title":"Acid sphingomyelinase is a gatekeeper of placental labyrinthine architecture and function","year":2025,"lang":"en","type":"article","venue":"Development","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; Occupational Cancer Research Centre; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Acid sphingomyelinase; Sphingolipid; Trophoblast; Cell biology; Sphingomyelin phosphodiesterase; Placenta; Ceramide; Sphingomyelin; Fetus; Autophagy; Endocrinology; Internal medicine; Genetics; Apoptosis; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008448114,0.0002722883,0.0001463015,0.0002391076,0.0001753405,0.0003101539,0.0001554773,0.0002179669,0.0005247834],"category_scores_gemma":[0.0001305541,0.0001087369,0.00009338304,0.0001204124,0.0002213997,0.0001522501,0.0002408159,0.0002501023,0.000241442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003244052,"about_ca_system_score_gemma":0.0002248724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005608529,"about_ca_topic_score_gemma":0.0004654093,"domain_scores_codex":[0.9999491,0.000006755151,0.000004663364,0.00001565844,0.00001364432,0.00001027249],"domain_scores_gemma":[0.9999338,0.000006793254,0.00002879584,0.000005517565,0.000005816106,0.00001916989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008582341,0.000003265267,0.0006880063,0.00003563191,0.000004654664,0.0002082054,0.00001383095,0.00006935294,0.9948223,0.0003000103,0.00005639424,0.003712466],"study_design_scores_gemma":[0.00001359835,0.00009076763,0.01873767,0.00001222339,0.0000139441,0.001775636,0.00005095707,0.0008174952,0.9675583,0.0003749606,0.01054754,0.00000685268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979214,0.01127292,0.006201202,0.0002845776,0.00003509669,0.00001877211,0.0005095582,0.0002091086,0.002254614],"genre_scores_gemma":[0.9930447,0.00258617,0.002089283,0.00002069995,0.000006918199,0.00001120321,0.0002772086,0.00001083461,0.00195307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005608529,"threshold_uncertainty_score":0.002353668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004580795469376837,"score_gpt":0.2254271785768492,"score_spread":0.2208463831074723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}