{"id":"W4413880037","doi":"10.1242/dev.204425","title":"Acid sphingomyelinase is a gatekeeper of placental labyrinthine architecture and function","year":2025,"lang":"en","type":"article","venue":"Development","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; Occupational Cancer Research Centre; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Acid sphingomyelinase; Sphingolipid; Trophoblast; Cell biology; Sphingomyelin phosphodiesterase; Placenta; Ceramide; Sphingomyelin; Fetus; Autophagy; Endocrinology; Internal medicine; Genetics; Apoptosis; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005369313,0.00006123939,0.00005650515,0.00003077585,0.00004352514,0.000006226558,0.00004273714,0.00004630765,0.00002875509],"category_scores_gemma":[0.000007059085,0.00005488619,0.00001636864,0.00005087192,0.0000262951,0.000001046124,0.00005423373,0.00003344733,0.000002041721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000101313,"about_ca_system_score_gemma":0.00007928527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005669191,"about_ca_topic_score_gemma":0.00001445295,"domain_scores_codex":[0.9996217,0.000007195504,0.0001067932,0.0001489573,0.00004670197,0.00006861155],"domain_scores_gemma":[0.9998063,0.00000153797,0.00002671874,0.0001099345,0.0000345443,0.0000209099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001485479,0.00005207387,0.003909725,0.00005526842,0.00009376338,4.246195e-7,0.0003885168,0.00001786497,0.8687258,0.0002418881,0.002916157,0.12345],"study_design_scores_gemma":[0.000331709,0.0000300879,0.02962486,0.00001911844,0.000008108142,0.000001847119,0.00008156451,0.000008997562,0.713859,0.00006608151,0.2558984,0.00007018191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899069,0.001076311,0.007504728,0.0003398804,0.00007116134,0.00008156349,0.000005786225,0.000004390708,0.001009268],"genre_scores_gemma":[0.9952821,0.00008804051,0.002320376,0.0004099076,0.00001985609,0.00002007715,0.00004228414,0.000004063045,0.001813268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2529823,"threshold_uncertainty_score":0.2238194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004580795469376837,"score_gpt":0.2254271785768492,"score_spread":0.2208463831074723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}