{"id":"W4413883404","doi":"10.1016/j.isci.2025.113465","title":"Toward biomimetic optogenetics: Drug-free activation of acute opiate reward","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Optogenetics; Neuroscience; Drug; Chemistry; Pharmacology; Nanotechnology; Medicine; Psychology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174766,0.0002254297,0.0001798719,0.0001353829,0.0001570331,0.0004681658,0.0003998804,0.0002981955,0.0007428965],"category_scores_gemma":[0.0002684826,0.0001352368,0.0001718042,0.00009849223,0.0006092881,0.000479937,0.0004421672,0.0007283669,0.0001954947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003745777,"about_ca_system_score_gemma":0.0003519296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003339804,"about_ca_topic_score_gemma":0.000953277,"domain_scores_codex":[0.9998879,0.00001348778,0.000007859066,0.00002843924,0.00004427975,0.00001802348],"domain_scores_gemma":[0.9998549,0.00003407822,0.00005587738,0.00002392079,0.00001200606,0.00001908358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002036779,0.00001177072,0.0001192473,0.00003806645,0.000003376247,0.00001794683,0.00001189964,0.000277177,0.9929731,0.002736008,0.00003734694,0.003753664],"study_design_scores_gemma":[0.000009429831,0.0001392268,0.001961709,0.00001819875,0.00001245139,0.0001418669,0.00002928066,0.005093719,0.9854339,0.0019998,0.005150708,0.000009741942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7842343,0.002430916,0.2014037,0.0016022,0.0003079524,0.0001090987,0.000286614,0.0004918512,0.009133343],"genre_scores_gemma":[0.9428452,0.001551664,0.05262505,0.0003814624,0.00003136159,0.00006618943,0.00007570296,0.0000931316,0.002330203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007428965,"threshold_uncertainty_score":0.002717733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04889217477873713,"score_gpt":0.3426406849698057,"score_spread":0.2937485101910686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}