{"id":"W4413883555","doi":"10.1016/j.ymthe.2025.08.046","title":"T cell exhaustion in poorly immunogenic HCC is partially rescued by checkpoint blockade but suppressed by oncolytic virotherapy","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"National Cancer Institute; National Institutes of Health; King's College London; Mayo Foundation for Medical Education and Research; University of Minnesota; Hyundai Hope On Wheels; National Institute of Allergy and Infectious Diseases; Mayo Clinic","keywords":"Oncolytic virus; Blockade; Immune checkpoint; Immune system; Cancer research; T cell; Immunotherapy; Biology; Cytotoxic T cell; Cell; Immunology; Virology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006615004,0.0004775289,0.000721296,0.0003786308,0.0001077192,0.0001029705,0.0004678267,0.0003803677,0.003327014],"category_scores_gemma":[0.00003116461,0.0004635153,0.000376822,0.000887102,0.0001630667,0.00008538555,0.00006184273,0.0007238198,0.00009372624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004835536,"about_ca_system_score_gemma":0.0004035185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007379758,"about_ca_topic_score_gemma":0.00001542332,"domain_scores_codex":[0.9964478,0.0003517481,0.0007242814,0.0008234084,0.0008032543,0.000849486],"domain_scores_gemma":[0.9982895,0.00008638225,0.0001190442,0.001151019,0.0001457569,0.0002083537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003752239,0.001023964,0.0005541963,0.00005751697,0.0002765339,0.0001117195,0.0004165593,0.00001469954,0.9699091,0.00001284712,0.008086015,0.0157846],"study_design_scores_gemma":[0.01231548,0.0008007872,0.0007394956,0.0001080699,0.00003969193,0.000008238764,0.0000786519,0.0004289694,0.8790779,0.0002182054,0.1058443,0.0003402106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682974,0.01889346,0.001733389,0.005670911,0.0001448856,0.002203547,0.00004378383,0.0001259189,0.002886748],"genre_scores_gemma":[0.9564433,0.005802717,0.0002665136,0.006210301,0.00007285296,0.0004038901,0.0001696665,0.0001593711,0.03047141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09775824,"threshold_uncertainty_score":0.9997817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066415550059916,"score_gpt":0.2920930423690289,"score_spread":0.2814288868684297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}