{"id":"W4413883555","doi":"10.1016/j.ymthe.2025.08.046","title":"T cell exhaustion in poorly immunogenic HCC is partially rescued by checkpoint blockade but suppressed by oncolytic virotherapy","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"National Cancer Institute; National Institutes of Health; King's College London; Mayo Foundation for Medical Education and Research; University of Minnesota; Hyundai Hope On Wheels; National Institute of Allergy and Infectious Diseases; Mayo Clinic","keywords":"Oncolytic virus; Blockade; Immune checkpoint; Immune system; Cancer research; T cell; Immunotherapy; Biology; Cytotoxic T cell; Cell; Immunology; Virology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440086,0.0002838119,0.0004389163,0.0002288141,0.0001496763,0.0003864055,0.000179106,0.0002208307,0.001366528],"category_scores_gemma":[0.0001954152,0.0001321473,0.0002581782,0.0001605141,0.0002453129,0.000263514,0.0002401922,0.0008882568,0.0003728722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122303,"about_ca_system_score_gemma":0.0002756045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005126785,"about_ca_topic_score_gemma":0.000503763,"domain_scores_codex":[0.999844,0.00002302689,0.00001513332,0.00001855882,0.00002474898,0.00007444968],"domain_scores_gemma":[0.9998909,0.00001978697,0.00002203236,0.00002487119,0.000006894339,0.00003543411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006618038,0.0001443941,0.0007275594,0.00003134061,0.00001529874,0.0001206634,0.00002408727,0.0003148607,0.9942602,0.0003615266,0.0001553263,0.003182992],"study_design_scores_gemma":[0.0001261383,0.001335737,0.01326673,0.000009667325,0.00004129832,0.0007947835,0.00008222949,0.003456413,0.9773772,0.0003098795,0.003188411,0.00001136405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977539,0.0005009288,0.0006548807,0.00005655666,0.00001995783,0.00001241582,0.0001078829,0.00006169646,0.0008317755],"genre_scores_gemma":[0.9989381,0.0001003689,0.0001402038,0.00001736266,0.000005294642,0.00001140225,0.000148048,0.00001066676,0.0006285685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366528,"threshold_uncertainty_score":0.004571497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066415550059916,"score_gpt":0.2920930423690289,"score_spread":0.2814288868684297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}