{"id":"W4413894884","doi":"10.1002/mnfr.70217","title":"AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma","year":2025,"lang":"en","type":"article","venue":"Molecular Nutrition & Food Research","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Food and Agriculture; Natural Sciences and Engineering Research Council of Canada; Uniwersytet Medyczny w Lodzi; Uniwersytet Łódzki; Walther Cancer Foundation; Purdue University; World Health Organization; U.S. Department of Agriculture","keywords":"Epigenetics; AMPK; Biology; HDAC3; Downregulation and upregulation; Cancer research; Pterostilbene; Histone; Cell biology; Kinase; Protein kinase A; Biochemistry; Gene; Histone deacetylase; Resveratrol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008546304,0.0001701177,0.00019574,0.0001535109,0.00011113,0.0001535529,0.0000929971,0.0001294088,0.001091103],"category_scores_gemma":[0.00007090443,0.00009573097,0.000190646,0.0001026498,0.0001679713,0.0001042525,0.0001487986,0.0002548166,0.0002080913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001770278,"about_ca_system_score_gemma":0.0001624812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005258604,"about_ca_topic_score_gemma":0.00112556,"domain_scores_codex":[0.9999619,0.000007925129,0.000003118805,0.000007855375,0.000008667603,0.00001053333],"domain_scores_gemma":[0.9999676,0.000003145899,0.00001161467,0.000004142722,0.000004994085,0.000008545783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00035091,0.0000234578,0.0006036102,0.00005012422,0.000009580382,0.00006395645,0.00001571712,0.00007477096,0.9964098,0.0001338999,0.00004197276,0.002222236],"study_design_scores_gemma":[0.00004842234,0.0005567818,0.03358475,0.0000134028,0.00005586675,0.0002828131,0.00006266896,0.0008288685,0.9601277,0.0001514315,0.004279048,0.000008325737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992766,0.003789685,0.001447026,0.0001434484,0.00002582494,0.00001507729,0.0001776286,0.00006967096,0.001565572],"genre_scores_gemma":[0.9964138,0.001549221,0.0003929918,0.0000446955,0.000007925013,0.00001217365,0.0001651602,0.000006945399,0.001407112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091103,"threshold_uncertainty_score":0.003650069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05740246204139034,"score_gpt":0.3714798240157022,"score_spread":0.3140773619743119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}