{"id":"W4413900232","doi":"10.1002/elps.70018","title":"Characterization of the Specific Binding Between Aptamers and Cytochrome <i>c</i> With Pressure‐Assisted Capillary Electrophoresis Frontal Analysis","year":2025,"lang":"en","type":"article","venue":"Electrophoresis","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Aptamer; Capillary electrophoresis; Cytochrome c; Chemistry; Binding constant; Electrophoresis; Biophysics; Biomolecule; Binding site; Chromatography; Biochemistry; Molecular biology; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394888,0.0002287234,0.0003972324,0.0002525657,0.0001853604,0.00003202332,0.0002153765,0.0001594532,0.000002589214],"category_scores_gemma":[0.00002315765,0.000158434,0.0001957063,0.001362987,0.0002149837,0.000006153528,0.00009363425,0.0001284159,1.8735e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003237065,"about_ca_system_score_gemma":0.0000671233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003203855,"about_ca_topic_score_gemma":0.00006442614,"domain_scores_codex":[0.9985998,0.0001333672,0.0003024876,0.0004753582,0.0002047633,0.0002842663],"domain_scores_gemma":[0.9991088,0.00001959049,0.0002325359,0.0004793955,0.0001149709,0.00004473858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001640461,0.00002682986,0.01893922,0.00001655885,0.001542766,0.000001009532,0.000009545762,0.000001519339,0.977931,0.00002013307,0.0001751121,0.001172206],"study_design_scores_gemma":[0.0001829662,0.0001577448,0.1376882,0.00002227655,0.001164543,0.000003190459,0.00001435552,0.00001238391,0.857112,0.000008961987,0.003467886,0.0001654925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995352,0.0008768109,0.003116898,0.0002087037,0.00001374667,0.0002184684,0.00005473355,0.00002460845,0.0001340817],"genre_scores_gemma":[0.9966794,0.001535688,0.0008377524,0.00008862471,0.00005903676,0.00001171394,0.0002292628,0.00001901603,0.0005395056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1208191,"threshold_uncertainty_score":0.6460749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003611024598961387,"score_gpt":0.2116726572135384,"score_spread":0.208061632614577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}