{"id":"W4413901637","doi":"10.1002/brb3.70774","title":"Neural Representations of Neuropsychiatric Symptoms in Alzheimer's Disease Continuum Using Pathology‐Based Functional Connectivity Analysis","year":2025,"lang":"en","type":"article","venue":"Brain and Behavior","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; National Research Foundation; Northern California Institute for Research and Education; University of Southern California; Pfizer; BioClinica; Biogen; Ministry of Science and ICT, South Korea; Ministry of Health and Welfare; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apathy; Neuroimaging; Functional magnetic resonance imaging; Positron emission tomography; Psychology; Structural equation modeling; Dementia; Amyloid (mycology); Neuroscience; Alzheimer's disease; Disease; Medicine; Internal medicine; Pathology; Machine learning; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057029,0.0001573553,0.0002951665,0.0007441675,0.0001994726,0.00002805802,0.00009439849,0.00004851719,0.0000311655],"category_scores_gemma":[0.002516367,0.0001590893,0.0001592071,0.001877543,0.000285283,0.0001384307,0.00009255914,0.0001483204,8.962256e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002475071,"about_ca_system_score_gemma":0.00009152242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008568983,"about_ca_topic_score_gemma":0.000200289,"domain_scores_codex":[0.9983314,0.00036535,0.0002923088,0.0006135734,0.0001978263,0.0001995473],"domain_scores_gemma":[0.9962984,0.003183888,0.0001179379,0.0002686596,0.00006524698,0.00006586903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001554429,0.0005617674,0.950286,0.00001266517,0.00004691902,0.00005625469,0.00003013709,0.001332261,0.0454298,0.0007332948,0.0002618409,0.001093648],"study_design_scores_gemma":[0.0008340655,0.00004183172,0.9862745,0.000007847578,0.0009725658,0.000004918672,0.00003271185,0.009569809,0.001962925,0.0001467776,0.00002463795,0.000127396],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951003,0.0001863608,0.0008048567,0.002913181,0.0004164148,0.0003523427,0.00008991355,0.00004259222,0.00009400555],"genre_scores_gemma":[0.9979398,0.000002495806,0.00007246503,0.001795107,0.00002526743,0.00007636449,0.000008468923,0.000008461793,0.00007159817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04346688,"threshold_uncertainty_score":0.6487472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04479037357348845,"score_gpt":0.3217899272182935,"score_spread":0.276999553644805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}