{"id":"W4413901637","doi":"10.1002/brb3.70774","title":"Neural Representations of Neuropsychiatric Symptoms in Alzheimer's Disease Continuum Using Pathology‐Based Functional Connectivity Analysis","year":2025,"lang":"en","type":"article","venue":"Brain and Behavior","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; National Research Foundation; Northern California Institute for Research and Education; University of Southern California; Pfizer; BioClinica; Biogen; Ministry of Science and ICT, South Korea; Ministry of Health and Welfare; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apathy; Neuroimaging; Functional magnetic resonance imaging; Positron emission tomography; Psychology; Structural equation modeling; Dementia; Amyloid (mycology); Neuroscience; Alzheimer's disease; Disease; Medicine; Internal medicine; Pathology; Machine learning; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006081212,0.0003085848,0.0002193536,0.001438607,0.0001646332,0.0006088118,0.0002416499,0.0002345702,0.0008401857],"category_scores_gemma":[0.002019371,0.0001135168,0.0004552896,0.0007125852,0.0002799626,0.0005629419,0.0004541356,0.0002218052,0.0000684337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973755,"about_ca_system_score_gemma":0.0001841589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002480153,"about_ca_topic_score_gemma":0.005154532,"domain_scores_codex":[0.9998122,0.00008100818,0.00001025384,0.00005247768,0.00002384309,0.00002030784],"domain_scores_gemma":[0.9995793,0.0002105553,0.0001302052,0.00002400557,0.00002695117,0.00002904068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001003758,0.0002456728,0.8654312,0.0002457738,0.001501334,0.000756942,0.001352578,0.01620887,0.02213005,0.002224078,0.0009683467,0.08793127],"study_design_scores_gemma":[0.00002952888,0.0001942822,0.9389472,0.00003503105,0.0001739784,0.0006564297,0.0004107185,0.05347772,0.0009555373,0.004791421,0.0003042359,0.00002395517],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928605,0.0001996701,0.005926336,0.00009116004,0.000002954106,0.00002265187,0.0003007982,0.00003121594,0.0005646292],"genre_scores_gemma":[0.9973502,0.00006931645,0.002237448,0.000006403187,0.000005005174,0.00002008057,0.0002360377,0.000003328205,0.00007213615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002480153,"threshold_uncertainty_score":0.00493145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04479037357348845,"score_gpt":0.3217899272182935,"score_spread":0.276999553644805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}