{"id":"W4413902183","doi":"10.3389/fimmu.2025.1655730","title":"Innate lymphoid cells in the spotlight: from biomarkers to blueprint for innovative immunotherapy","year":2025,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Innate lymphoid cell; Blueprint; Immunotherapy; Medicine; Immunology; Tumor immunology; Innate immune system; Immune system; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001488224,0.0006452974,0.001168772,0.001140366,0.0003748764,0.002314774,0.0008622224,0.002162914,0.005355993],"category_scores_gemma":[0.001533731,0.0002872399,0.0004755171,0.0006535592,0.001279396,0.004086767,0.001158013,0.004326019,0.002367116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000973388,"about_ca_system_score_gemma":0.001769262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002882204,"about_ca_topic_score_gemma":0.0006844887,"domain_scores_codex":[0.9994645,0.0001610168,0.0000493841,0.00008495968,0.0001661469,0.00007413122],"domain_scores_gemma":[0.9992942,0.0003037902,0.00005927813,0.00002831403,0.0001689609,0.0001454771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005417217,0.0002096506,0.001273395,0.006985844,0.0001126612,0.0007111442,0.0002061759,0.0007528812,0.02091689,0.04033293,0.1301824,0.7977743],"study_design_scores_gemma":[0.0000790876,0.0004967961,0.001046926,0.002374875,0.0001015623,0.001836791,0.0003876126,0.0006531424,0.004186157,0.0375423,0.9512443,0.00005049254],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001068184,0.9758079,0.002106831,0.01569907,0.003060654,0.00001696997,0.00008838433,0.00007241007,0.002079496],"genre_scores_gemma":[0.01319094,0.959443,0.003023423,0.0115516,0.00813158,0.00006219704,0.0002639322,0.00002725029,0.004306068],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005355993,"threshold_uncertainty_score":0.01791757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682194210881799,"score_gpt":0.2742321804371358,"score_spread":0.2574102383283178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}