{"id":"W4413908212","doi":"10.1021/acsomega.5c05423","title":"Covalently Oriented AuNP–Antibody Bioconjugates Enable Early and Sensitive Detection of <i>Opisthorchis viverrini</i> Urinary Antigen","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Associated Medical Services","funders":"Khon Kaen University","keywords":"Opisthorchis viverrini; Antigen; Opisthorchiasis; Antibody; Urinary system; Chemistry; Covalent bond; Biology; Immunology; Medicine; Pathology; Liver fluke; Helminths; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106138,0.0003593343,0.0001543316,0.0001472566,0.00008588665,0.000188888,0.000196891,0.0003596458,0.0003743846],"category_scores_gemma":[0.0002744099,0.000135879,0.0001989495,0.00007868286,0.0002203358,0.0001687422,0.0001966032,0.000275625,0.0001338686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913782,"about_ca_system_score_gemma":0.00009537825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003238802,"about_ca_topic_score_gemma":0.0005329956,"domain_scores_codex":[0.9998407,0.00002494541,0.00001131688,0.00004689082,0.00004648387,0.00002958106],"domain_scores_gemma":[0.9999024,0.00002514824,0.00003766912,0.000006962434,0.00001906495,0.000008741748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001699099,0.000007716076,0.0001783255,0.00003335461,0.00000375822,0.00001914401,0.000009259016,0.00005621684,0.998337,0.00004325621,0.00001741829,0.001277368],"study_design_scores_gemma":[0.000003278386,0.000148784,0.001843052,0.000003127548,0.00000959048,0.0001095017,0.00001054544,0.001117112,0.9958253,0.00001699571,0.0009088166,0.00000382279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785191,0.001044486,0.01859455,0.000127553,0.00003481538,0.000042418,0.00007309064,0.0001356492,0.001428417],"genre_scores_gemma":[0.9818794,0.0007099322,0.01581094,0.0001145489,0.00001174339,0.0000452833,0.0001116161,0.00001139497,0.001305268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003743846,"threshold_uncertainty_score":0.00138855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004430960321782122,"score_gpt":0.2619501290615883,"score_spread":0.2575191687398061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}