{"id":"W4413912343","doi":"10.1021/acsptsci.5c00361","title":"Toward Long-Acting Psoriasis Therapy with Phloretin-Loaded Microneedle Patches: Insights from <i>In Vitro</i> Patient-Derived Skin Models","year":2025,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Université de Montréal; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Université Laval","keywords":"Psoriasis; Phloretin; In vitro; Medicine; Chemistry; Dermatology; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002013347,0.0002275639,0.0002859734,0.0001176665,0.0001224623,0.0002897487,0.0001806699,0.0002921985,0.0006012397],"category_scores_gemma":[0.0000912375,0.00009141124,0.0002495854,0.00007328481,0.0001234398,0.0001752703,0.00011847,0.000539134,0.0002075862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000185785,"about_ca_system_score_gemma":0.0001167217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004619774,"about_ca_topic_score_gemma":0.0006539063,"domain_scores_codex":[0.9998823,0.00004088785,0.000006978302,0.00001831347,0.00003146803,0.00001990544],"domain_scores_gemma":[0.9999527,0.00001321336,0.00001015474,0.000008059567,0.000006951757,0.000009055257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006606727,0.00008893773,0.00006102158,0.00005758133,0.000003507646,0.00005034652,0.00001927539,0.0001443273,0.9976327,0.00005332471,0.00004952628,0.001773304],"study_design_scores_gemma":[0.00002072242,0.001365305,0.001172999,0.00001012171,0.00002361173,0.0003583145,0.00003313086,0.001685381,0.9927725,0.00005113464,0.002500948,0.000005762674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745116,0.006354928,0.01550243,0.0003110162,0.00006949757,0.0001517456,0.0003386408,0.0001147831,0.002645315],"genre_scores_gemma":[0.9853779,0.00383212,0.008806806,0.000107199,0.00001998231,0.00007144157,0.0002829139,0.00001643932,0.001485152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006012397,"threshold_uncertainty_score":0.002011299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02436382244130248,"score_gpt":0.2613500801609772,"score_spread":0.2369862577196747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}