{"id":"W4413914719","doi":"10.1001/jamanetworkopen.2025.29427","title":"Measurement-Based Care to Enhance Antidepressant Treatment Outcomes in Major Depressive Disorder","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Treatment of Major Depression","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Major depressive disorder; Medicine; Paroxetine; Rating scale; Depression (economics); Psychological intervention; Mirtazapine; Randomized controlled trial; Hamilton Rating Scale for Depression; Psychiatry; Antidepressant; Adverse effect; Clinical trial; Physical therapy; Internal medicine; Psychology; Mood; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00683874,0.0004057024,0.001173778,0.0003651487,0.0003236842,0.0007340288,0.0004889703,0.0008685506,0.002730018],"category_scores_gemma":[0.01312522,0.000188848,0.0009744206,0.0005649544,0.0004295603,0.0006006657,0.0007340313,0.001096902,0.0001904262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006641155,"about_ca_system_score_gemma":0.001807279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009318308,"about_ca_topic_score_gemma":0.001631108,"domain_scores_codex":[0.993879,0.004523054,0.000520236,0.0002479287,0.0006190978,0.0002107851],"domain_scores_gemma":[0.9962105,0.001705913,0.001210506,0.0002307576,0.0002567153,0.0003856877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.08843026,0.01995469,0.03774907,0.007795426,0.002519744,0.00005812295,0.0004733824,0.001291499,0.001890339,0.001741039,0.006665178,0.8314313],"study_design_scores_gemma":[0.303929,0.2573089,0.3895586,0.007623118,0.006465804,0.0002775223,0.0003975686,0.008022034,0.002825739,0.00448682,0.01894872,0.0001560847],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9105135,0.03815738,0.009987437,0.01059509,0.001972232,0.015701,0.001236656,0.0002648377,0.01157193],"genre_scores_gemma":[0.974901,0.004137094,0.01370641,0.001431735,0.0004234435,0.004723023,0.0002589565,0.000008138671,0.0004101352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00683874,"threshold_uncertainty_score":0.03616714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013399342384321,"score_gpt":0.3341605857636542,"score_spread":0.314026592339811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}