{"id":"W4413915917","doi":"10.1016/j.redox.2025.103856","title":"Oxidatively damaged DNA in DNA repair-deficient and ethanol-exposed fetal brains induces gene dysregulation and mitochondrial dysfunction associated with neurodevelopmental disorders","year":2025,"lang":"en","type":"article","venue":"Redox Biology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Provincial Health Services Authority; University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto","keywords":"Mitochondrial DNA; DNA damage; Fetus; Gene; Biology; DNA; DNA repair; Genetics; Cell biology; Molecular biology; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855696,0.0002004554,0.0002192749,0.0001437491,0.0001071875,0.00001926316,0.00007912652,0.0002527514,0.000005254424],"category_scores_gemma":[0.0002002539,0.0001794482,0.00003461308,0.0002210443,0.0002447952,0.000007961821,0.0001125355,0.0001034132,5.287739e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001036387,"about_ca_system_score_gemma":0.00009709678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003716633,"about_ca_topic_score_gemma":0.0005487347,"domain_scores_codex":[0.9986169,0.0002380004,0.0002473106,0.0005704392,0.00007174848,0.0002556549],"domain_scores_gemma":[0.99961,0.00003427286,0.0001011124,0.000167909,0.00003965644,0.00004705357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002667908,0.00009868862,0.04389279,0.00001054836,0.00008908231,9.596432e-7,0.0001820836,0.00001695378,0.9470806,0.0001061499,0.000107705,0.008147619],"study_design_scores_gemma":[0.003860211,0.0006214865,0.8924661,0.00002599403,0.00004658382,0.000005276115,0.0003780703,0.0001322159,0.09954838,0.0002827398,0.002297932,0.0003350452],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974786,0.0006041613,0.0005632895,0.0002603001,0.0002678967,0.0003627181,0.00002567491,0.0000228413,0.0004145386],"genre_scores_gemma":[0.998023,0.0003346645,0.0005873388,0.0001895652,0.00003215087,0.00003046817,0.0005213349,0.00001325909,0.0002681994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8485733,"threshold_uncertainty_score":0.7317686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006574761826148603,"score_gpt":0.2257407285818788,"score_spread":0.2191659667557302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}