{"id":"W4413919517","doi":"10.1073/pnas.2503145122","title":"HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ARC Centre for Excellence in Convergent Bio-Nano Science and Technology; National Institute of Allergy and Infectious Diseases; Health and Medical Research Fund; Institute of Infection and Immunity; National Health and Medical Research Council; University of California, Los Angeles; National Institutes of Health; Chinese University of Hong Kong; University of Hong Kong; Innovation and Technology Commission; Monash University; Children's Hospital Los Angeles; Department of Health and Aged Care, Australian Government; Queen Mary University of London; St. Jude Children's Research Hospital; National Institute for Health and Care Research; University of Oxford; Monash Biomedicine Discovery Institute, Monash University; National Institute for Health Research Health Protection Research Unit; Medical Research Council; Menzies School of Health Research; Department of Health and Social Care; Murdoch Children's Research Institute; UK Research and Innovation; UK Coronavirus Immunology Consortium; Children’s Hospital of Wisconsin Research Institute","keywords":"Asymptomatic; CD8; Immunology; Cytotoxic T cell; Human leukocyte antigen; T cell; T-cell receptor; Coronavirus disease 2019 (COVID-19); Disease; Immune system; Medicine; Biology; Antigen; Infectious disease (medical specialty); Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036177,0.0001542189,0.0001714296,0.000110093,0.0001374203,0.0003085078,0.00009621346,0.0001385422,0.001909972],"category_scores_gemma":[0.0001898419,0.00008721219,0.00009494875,0.00009019468,0.0001885143,0.000162063,0.0002374308,0.0002702719,0.0003551335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007979413,"about_ca_system_score_gemma":0.00007200747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006418696,"about_ca_topic_score_gemma":0.0007666072,"domain_scores_codex":[0.9998971,0.00001603912,0.00001292248,0.00003024879,0.00001455876,0.00002916645],"domain_scores_gemma":[0.9998531,0.00002192694,0.00004355945,0.00001796485,0.00001886559,0.00004459958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007841248,0.00008797413,0.1731416,0.00007092034,0.00004217633,0.0006685116,0.0004356982,0.0002147319,0.8147025,0.000131911,0.0002383961,0.009481366],"study_design_scores_gemma":[0.00004674856,0.001621516,0.9382759,0.00002198208,0.00004980057,0.005631142,0.000946956,0.001115565,0.0488968,0.0001803923,0.003201231,0.00001191953],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992342,0.00006622269,0.0001586103,0.00001218758,0.000002288118,0.00000636857,0.00006945692,0.000005952856,0.0004446776],"genre_scores_gemma":[0.9993799,0.00003620639,0.0001328457,0.00003644278,0.000002955185,0.000004742057,0.0001615549,0.000002599479,0.0002428329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001909972,"threshold_uncertainty_score":0.006389499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05340610312946611,"score_gpt":0.3527761622574138,"score_spread":0.2993700591279477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}