{"id":"W4413919645","doi":"10.1093/infdis/jiaf450","title":"VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Antidrug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results","year":2025,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada); McGill University Health Centre","funders":"ViiV Healthcare","keywords":"Pharmacokinetics; Medicine; Adverse effect; Incidence (geometry); Pharmacology; Drug; Pharmacodynamics; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002640365,0.0006237865,0.0007484291,0.0001755242,0.0001796693,0.0003865263,0.000433472,0.0004023964,0.002988754],"category_scores_gemma":[0.001072106,0.0002023909,0.0004551189,0.0001631369,0.0003081711,0.0006578302,0.0003709789,0.0007882846,0.0005874005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752164,"about_ca_system_score_gemma":0.000358429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004406113,"about_ca_topic_score_gemma":0.001012955,"domain_scores_codex":[0.9990387,0.0005179462,0.00007151882,0.0001394685,0.0001753558,0.00005699775],"domain_scores_gemma":[0.99876,0.0002917681,0.000387911,0.0001041559,0.0001517861,0.0003043549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3310992,0.02534241,0.3792887,0.001329266,0.003198187,0.0003814319,0.0007410978,0.001328657,0.05500251,0.0004546074,0.004294972,0.197539],"study_design_scores_gemma":[0.1102367,0.2777447,0.5776262,0.0002472989,0.002467282,0.001707241,0.000335781,0.002456719,0.01348254,0.0004777246,0.01307081,0.0001470061],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957261,0.001193741,0.0001596583,0.0001131986,0.00001717407,0.000219185,0.0007872031,0.00001498172,0.001768701],"genre_scores_gemma":[0.9952574,0.0005801385,0.0007683589,0.0002384785,0.0000581629,0.0002992401,0.00138702,0.00001082299,0.001400309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002988754,"threshold_uncertainty_score":0.01396376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006278899455025522,"score_gpt":0.2779339313619065,"score_spread":0.271655031906881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}